Measuring Drug Activity
The development of drugs starts with the recognition that some particular pharmacological effect may be useful therapeutically. Sometimes an application can be seen before there is a compound with the desired properties. Past history often suggests the reverse: several important drugs, such as the sulphonamides, have been made by the chemist years before their therapeutic value was realised. In either situation an initial discovery depends upon both an understanding of what may be useful and upon a knowledge of what drugs do; it requires both the flash of genius and the humdrum collection of pharmacological information.
KeywordsTest Solution Quantitative Aspect Effect Difference Test Preparation Potency Ratio
Unable to display preview. Download preview PDF.
- 1.J. H. Gaddum, Nature (1945), no. 156, p. 463; Pharmacol. Rev. (1953), no. 5, p. 87.Google Scholar
- 2.J. H. Gaddum, Pharmacol. Rev. (1953), no. 5, p. 87; Journal Pharm. Pharmacol. (1953), no. 6, p. 345; British Pharmacopoeia (1967), Appendix XV (not in subsequent issues); European Pharmacopoeia H (1971), p. 441–98.Google Scholar
- 3.D. J. Finney, Statistical Method in Biological Assay, 2nd edn (Griffin, London, 1964); D. Colquhoun, Lectures on Biostatistics (Oxford University Press, 1971 ).Google Scholar
- 4.J. T. Litchfield and F. Wilcoxon, Journal Pharmacol. (1949), no. 96, p. 99.Google Scholar
- 5.A. J. Clark, The Mode of Action of Drugs on Cells (Arnold, London, 1933); Handbuch der Experimentellen Pharmakologie IV (Springer, Berlin, 1937) (in English, reprinted 1973 ).Google Scholar
- 6.J. N. Langley, Journal Physiol. (1905), no. 33, p. 374.Google Scholar
- 7.P. Ehrlich, Münch. Med. Wschr. (1909), p. 217.Google Scholar