Dementia and its Relation to Cerebrovascular Disease

  • S. Hoyer


According to Mayer-Gross, Slater and Roth (1), dementia is based on a global deterioration of higher mental functions and intellectual capacities. It may be defined as a global disturbance of mental functioning in its cognitive, intellectual and emotional aspects. McHugh and Folstein (2) defined dementia as a deterioration of cognitive functions including memory, abstract reasoning, attention, language and perception without prominent changes in consciousness. Disturbances in mood with anxiety and depression, in affectiveness, paranoid symptoms, delusions, hallucinations, personality changes and catastrophic reactions were also described to be associated with dementia. For clinical and pathophysiological reasons, primary and secondary forms of dementia should necessarily be separated. According to Sir Martin Roth (3), secondary dementia symptoms will have been of relatively short duration with rather abrupt onset. Their intellectual impairment may be patchy and inconsistent and may show marked fluctuations in severity as related to the severity of the extracerebral disease. Clouding and confusion would seem to be typical in secondary rather than primary dementia. In this paper, only secondary dementias due to circulatory disorders will be discussed.


Cerebral Blood Flow Hypertensive Encephalopathy Brain Blood Flow Vascular Type High Mental Function 
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  1. 1.
    W. Mayer-Gross, E. Slater, M. Roth, CLinical Psychiatrie, 3rd ed. Bailliere, Tindall and Carssell, London (1969)Google Scholar
  2. 2.
    P. R. McHugh and M. F. Folstein, Psychopathology of dementia: Implications for neuropathology, in:Congenital and aquired cognitive disorders, R. Katzman, ed., Raven, New York (1979)Google Scholar
  3. 3.
    Sir Martin Roth, Diagnosis of senile and related forms of dementia, in: Alzheiner’s disease: Senile dementia and related disorders (Aging Vol.7), R. Katzman, R. D. Terry, K. L. Bick, eds., Raven, New York (1978)Google Scholar
  4. 5.
    U. Gottstein, A. Bernsmeier, H. Blömer, and W. Schimmler, Die zerebrale Häamodynamik bei Kranken mit Mitralstenose und kombiniertem Nitralvitium, Klin. Wschr. 38, 1025 (1960)PubMedCrossRefGoogle Scholar
  5. 6.
    A. Bernsmeier, U. Gottstein, and W. Rudolph, Herz krankheiten als Ursache zerebraler Zirkulationsstörungen, Dtsch. Med. Wschr. 87, 16 (1962)PubMedCrossRefGoogle Scholar
  6. 7.
    S. Eisenberg and W. Sensenbach, J. Clin. Invest. 35, 700 (1956)Google Scholar
  7. 8.
    L. Wollner, S. T. McCarthy, N. D. W. Soper, and D. J. Macy, Failure of cerebral autoregulation as a cause of brain dysfunction in the elderly, Br. Med. J. I., 1117 (1979)CrossRefGoogle Scholar
  8. 9.
    W. B. Kannel, P. A. Wolf, J. Verter, and P. M. Mc Namara, Epidemiologic assessment of the role of blood pressure in stroke. The Framingham study, J. Amer. Med. Ass. 214, 301 (1970)CrossRefGoogle Scholar
  9. 10.
    U. Gottstein, Zur Pathogenese der Hirnischämie, unter besonderer Berücksichtigung der Risikofaktoren, Internist 17, 1 (1976)PubMedGoogle Scholar
  10. 11.
    S. S. Kety, J. H. Hafkenschiel, W. A. Jeffers, J. H. Leopold, and H. A. Shenkin, Blood flow, vascular resistence and oxygen consumption of the brain in essential hypertension. J. Clin. Invest. 27, 511 (1948)CrossRefGoogle Scholar
  11. 12.
    S. Strandgaard, J. Olesen, E. Skinhtfsj, and N. A. Lassen, Autoregulation of brain circulation in severe arterial hypertension. Brit. Med. J. I, 507 (1973)CrossRefGoogle Scholar
  12. 13.
    N. A. Lassen and A. Agnoli, Upper limit of autoregulation of cerebral blood flow: on the pathogenesis of hypertensive encephalopathy, Scand. J. Clin. Lab. Invest. 30, 113 (1972)PubMedCrossRefGoogle Scholar
  13. 14.
    H. A. Shenkin, P. Novack, B. Gohnboff, A.M. Soffe, and L. Bortin, J. Clin. Invest. 32, 459 (1953)PubMedCrossRefGoogle Scholar
  14. 15.
    R. N. Butler, D. K. Dastur, and S. Perlin, Relationships of senile manifestations and chronic brain syndromes to cerebral circulation and metabolism, J. Psychiat. Res. 3, 229 (1965)PubMedCrossRefGoogle Scholar
  15. 16.
    G. Blessed, Clinical aspects of senile dementia, in: Biochemistry of dementia, P. J. Roberts, ed., Wiley, Chichester (1980)Google Scholar
  16. 17.
    J. A. N. Corsellis, The pathology of dementia, Br. J. Hosp. Med. 3, 695 (1969)Google Scholar
  17. 18.
    M. D. O’Brien and B. L. Mallett, Cerebral cortex perfusion rates in dementia, J. Neurol. Neurosurg. Psychiat. 33 497 (1970)PubMedCrossRefGoogle Scholar
  18. 19.
    V. C. Hachinski, L. D. Iliff, E. Zilkha, G. H. DuBoulay, V. L. McAllister, J. Marshall, R. W. Ross- Russell, and L. Symon; Cerebral blood flow in dementia, Arch. Neurol. 32, 632 (1975)Google Scholar
  19. 20.
    G. Ladurner, E. O. Ott, P. J. Perry, P. Stix, H. Schreyer, F. Wiedner, and H. Lechner, Bilateral measurement of regional cerebral blood flow in dementia, in:Cerebral Vascular Disease, eds.: J. S. Meyer, H. Lechner, M. Reivich, Excerpta Medica, Amsterdam, Oxford (1977)Google Scholar
  20. 21.
    S. Hoyer, K. Oesterreich, F. Weinhardt, and G. Krüger, Veränderungen von Durchblutung und oxidativem Stoffwechsel des Gehirns bei Patienten mit einer Demenz, J. Neurol. 210, 227 (1975)PubMedCrossRefGoogle Scholar
  21. 22.
    J. Hamer, K. Wiedemann, H. Beriet, F. Weinhardt, and S. Hoyer, Cerebral glucose and energy metabolism, cerebral oxygen consumption and blood flow in arterial hypoxemia, Acta Neurochir. 44, 151 (1978)PubMedCrossRefGoogle Scholar
  22. 23.
    J. Klatzo, E. Fargas-Bergeton, L. Guth, J. Miguel, and Y. Olsson, Some morphological and biochemical apects of abnormal glycogen accumulation in the glia, in Proceed. Vlth Int. Congr. Neuropathol., Masson, Paris (1970)Google Scholar
  23. 24.
    M. J. Mossakowski, D. M. Long, R. E. Myers, H. Rodriguez de Curet, and J. Klatzo, Early histo-chemi- cal changes in perinatal asphyxia, J. Neuropathol. Exp. Neurol. 27, 500 (1968)CrossRefGoogle Scholar
  24. 25.
    S. Hoyer, Factors influencing cerebral blood flow, CMR-oxygen and CMR-glucose in dementia patients, in: Biochemsitry of dementia, P. J. Roberts, ed., Wiley, Chichester (1980)Google Scholar
  25. 26.
    W. D. Obrist, Noninvasive Studies of cerebral blood flow in aging and dementia, in: Alzheimer’s disease: Senile dementia and related disorders, R. Katzman, R. D. Terry, K. L. Bick, eds., Raven, New York (1978)Google Scholar

Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • S. Hoyer
    • 1
  1. 1.Dept. of Pathochemistry and General NeurochemistryUniversity of HeidelbergHeidelbergGermany

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