Dementia and its Relation to Cerebrovascular Disease
According to Mayer-Gross, Slater and Roth (1), dementia is based on a global deterioration of higher mental functions and intellectual capacities. It may be defined as a global disturbance of mental functioning in its cognitive, intellectual and emotional aspects. McHugh and Folstein (2) defined dementia as a deterioration of cognitive functions including memory, abstract reasoning, attention, language and perception without prominent changes in consciousness. Disturbances in mood with anxiety and depression, in affectiveness, paranoid symptoms, delusions, hallucinations, personality changes and catastrophic reactions were also described to be associated with dementia. For clinical and pathophysiological reasons, primary and secondary forms of dementia should necessarily be separated. According to Sir Martin Roth (3), secondary dementia symptoms will have been of relatively short duration with rather abrupt onset. Their intellectual impairment may be patchy and inconsistent and may show marked fluctuations in severity as related to the severity of the extracerebral disease. Clouding and confusion would seem to be typical in secondary rather than primary dementia. In this paper, only secondary dementias due to circulatory disorders will be discussed.
KeywordsCerebral Blood Flow Hypertensive Encephalopathy Brain Blood Flow Vascular Type High Mental Function
Unable to display preview. Download preview PDF.
- 1.W. Mayer-Gross, E. Slater, M. Roth, CLinical Psychiatrie, 3rd ed. Bailliere, Tindall and Carssell, London (1969)Google Scholar
- 2.P. R. McHugh and M. F. Folstein, Psychopathology of dementia: Implications for neuropathology, in:Congenital and aquired cognitive disorders, R. Katzman, ed., Raven, New York (1979)Google Scholar
- 3.Sir Martin Roth, Diagnosis of senile and related forms of dementia, in: Alzheiner’s disease: Senile dementia and related disorders (Aging Vol.7), R. Katzman, R. D. Terry, K. L. Bick, eds., Raven, New York (1978)Google Scholar
- 7.S. Eisenberg and W. Sensenbach, J. Clin. Invest. 35, 700 (1956)Google Scholar
- 16.G. Blessed, Clinical aspects of senile dementia, in: Biochemistry of dementia, P. J. Roberts, ed., Wiley, Chichester (1980)Google Scholar
- 17.J. A. N. Corsellis, The pathology of dementia, Br. J. Hosp. Med. 3, 695 (1969)Google Scholar
- 19.V. C. Hachinski, L. D. Iliff, E. Zilkha, G. H. DuBoulay, V. L. McAllister, J. Marshall, R. W. Ross- Russell, and L. Symon; Cerebral blood flow in dementia, Arch. Neurol. 32, 632 (1975)Google Scholar
- 20.G. Ladurner, E. O. Ott, P. J. Perry, P. Stix, H. Schreyer, F. Wiedner, and H. Lechner, Bilateral measurement of regional cerebral blood flow in dementia, in:Cerebral Vascular Disease, eds.: J. S. Meyer, H. Lechner, M. Reivich, Excerpta Medica, Amsterdam, Oxford (1977)Google Scholar
- 23.J. Klatzo, E. Fargas-Bergeton, L. Guth, J. Miguel, and Y. Olsson, Some morphological and biochemical apects of abnormal glycogen accumulation in the glia, in Proceed. Vlth Int. Congr. Neuropathol., Masson, Paris (1970)Google Scholar
- 25.S. Hoyer, Factors influencing cerebral blood flow, CMR-oxygen and CMR-glucose in dementia patients, in: Biochemsitry of dementia, P. J. Roberts, ed., Wiley, Chichester (1980)Google Scholar
- 26.W. D. Obrist, Noninvasive Studies of cerebral blood flow in aging and dementia, in: Alzheimer’s disease: Senile dementia and related disorders, R. Katzman, R. D. Terry, K. L. Bick, eds., Raven, New York (1978)Google Scholar