Peptides in Major Psychoses

  • Ole J. Rafaelsen


During the last decades, biological interest in depression has focused on neuroendocrinological disturbances. Accordingly the involvement of minor peptide hormones present in the brain have been hypothesized and studied. Thus an impaired thyrotropin (TSH) response to thyrotropin releasing hormone (TRH) has been described (Prange et al., 1972; Kastin et al., 1972), and furthermore Kirkegaard et al. (1975) and Kirkegaard and Smith (1978) showed that changes in TSH response to TRH during electroconvulsive therapy (ECT) seem to be of predictive value for the post-treatment course of the disease. Moreover, Kirkegaard et al. (1979), reported high levels of TRH in cerebrospinal fluid (CSF) in endogenous depression.


Growth Hormone Schizophrenic Patient Vasoactive Intestinal Polypeptide Thyrotropin Release Hormone Electroconvulsive Therapy 
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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Ole J. Rafaelsen
    • 1
  1. 1.Psychochemistry Institute & Department of Psychiatry RigshospitaletCopenhagenDenmark

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