Plasma Levels and the Management of Chronic, Refractory Schizophrenia
Thiothixene has a rather long clinical use as an antipsychotic drug.1 It ranks with haloperidol and fluphenazine as being a highly potent, somewhat specific neuroleptic. Drugs of this type can be used in much higher antipsychotic doses than low-potency, less specific drugs. Many patients are regularly treated with doses of thiothixene in excess of 100 mg/day. Few data have been accumulated in any systematic way about the effects of doses in the 100 to 400 mg/day range in patients refractory to lower doses of this or equivalent drugs. Therefore, we elected to use thiothixene to treat refractory patients, using such doses if needed.
KeywordsPlasma Concentration Antipsychotic Drug Clinical Global Impression Paranoid Schizophrenia Therapeutic Plasma Concentration
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