Lithium Transport in Brain Cells and Human Erythrocytes

  • István Szentistványi
  • Zoltán Janka


Many data have been accumulated, largely due to the Chicago and Munich groups, over the last decade regarding the basic mechanisms of lithium ion /Li+/ transport across the red cell membrane /Duhm and Becker, 1977; Pandey et al., 1978; Tosteson, 1981/. The important discovery is that the steady state intra: extracellular Li+ concentration ratio in the human blood is determined by the Na+-Li+ counterflow system /Haas et al., 1975; Duhm et al., 1976/. Clinically and physiologically important new directions have been emanated from studying this transport system in patients with manic-depressive illness and their relatives /Ostrow et al., 1978; Pandey et al., 1979; Ramsey et al., 1979; Szentistványi and Janka, 1979 a, b; Mendlewicz and Verbanck, 1981; Dorus et al., 1979, 1983/, in populations with other medical diseases believed to be partially determined by genetic factors /Canessa et al., 1980/ and also in the light of environmental and pharmacological influences /Ostrow et al., 1980/.


Brain Cell Ionic Medium Affective Psychosis Transport Research Membrane Transport Process 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • István Szentistványi
    • 1
  • Zoltán Janka
    • 1
  1. 1.Department of Neurology and PsychiatryUniversity Medical School of SzegedSzegedHungary

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