Lithium Transport in Brain Cells and Human Erythrocytes

  • István Szentistványi
  • Zoltán Janka


Many data have been accumulated, largely due to the Chicago and Munich groups, over the last decade regarding the basic mechanisms of lithium ion /Li+/ transport across the red cell membrane /Duhm and Becker, 1977; Pandey et al., 1978; Tosteson, 1981/. The important discovery is that the steady state intra: extracellular Li+ concentration ratio in the human blood is determined by the Na+-Li+ counterflow system /Haas et al., 1975; Duhm et al., 1976/. Clinically and physiologically important new directions have been emanated from studying this transport system in patients with manic-depressive illness and their relatives /Ostrow et al., 1978; Pandey et al., 1979; Ramsey et al., 1979; Szentistványi and Janka, 1979 a, b; Mendlewicz and Verbanck, 1981; Dorus et al., 1979, 1983/, in populations with other medical diseases believed to be partially determined by genetic factors /Canessa et al., 1980/ and also in the light of environmental and pharmacological influences /Ostrow et al., 1980/.


Brain Cell Ionic Medium Affective Psychosis Transport Research Membrane Transport Process 


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  1. Canessa, M., et al., 1980, N.Engl.J.Med., 302:772PubMedCrossRefGoogle Scholar
  2. Dorus, E., et al.,1979, Science,205:934CrossRefGoogle Scholar
  3. Dorus, E., et al.,1983, Arch.Gen.Psychiat.,40:545PubMedCrossRefGoogle Scholar
  4. Duhm, J., et al,1976, Pflügers Arch.,364:147PubMedCrossRefGoogle Scholar
  5. Duhm, J.,. and Becker, B.F.,1977, Pflügers Arch.,367:211PubMedCrossRefGoogle Scholar
  6. Gorkin, R. A. and Richelson, E.,1979, Brain Res.,171:365PubMedCrossRefGoogle Scholar
  7. Gorkin, R. A. and Richelson, E., 1981, Neuropharm.,20:791CrossRefGoogle Scholar
  8. Grafe, P., et al., 1982, Pflügers Arch.,393:297PubMedCrossRefGoogle Scholar
  9. Haas, M., et al., 1975, Nature/Lond./,258:425CrossRefGoogle Scholar
  10. Janka, Z., et al.,1979, Acta Neuropathol.,46:117PubMedCrossRefGoogle Scholar
  11. Janka, Z., et al.,1980a, Experientia,36:1071Google Scholar
  12. Janka, Z., et al.,1980b, Neuropharmacol.,19:827CrossRefGoogle Scholar
  13. Janka, Z., et al.,1980c, Psychopharmacol.,71:159CrossRefGoogle Scholar
  14. Janka, Z., et al.,1981, Acta Neuropathol.Suppl.,VII:44CrossRefGoogle Scholar
  15. Janka, Z., and Jones, DG, 1982a, Brain Res.,237:261PubMedCrossRefGoogle Scholar
  16. Janka, Z. and Jones, DG, 1982b, Neuroscience,7:2849PubMedCrossRefGoogle Scholar
  17. Mendlewicz, J. and Verbanck, PMP.,1981, Am.J.Psychiat., 138:119PubMedCrossRefGoogle Scholar
  18. Nelson, P. G.,1975, Physiol.Rev.,55:1PubMedCrossRefGoogle Scholar
  19. Ostrow, D. G.,et al.,1978, Am.J.Psychiat.,135:1070PubMedGoogle Scholar
  20. Ostrow, D. G.,et al., 1980, Biol.Psychiat.,15:723PubMedGoogle Scholar
  21. Pandey, G. N., et al.,1978, J.Gen.Physiol.,72:233PubMedCrossRefGoogle Scholar
  22. Pandey, G. N., et al.,1979, Arch.Gen.Psychiat.,36:902PubMedCrossRefGoogle Scholar
  23. Ramsey, T. A., et al.,1979, Arch.Gen.Psychiat.,36:457PubMedCrossRefGoogle Scholar
  24. Reiser, G. and Duhm, J.,1982, Brain Res.,252:247PubMedCrossRefGoogle Scholar
  25. Reiser, G.,et al.,1982, J.Neurochem.,39:228PubMedCrossRefGoogle Scholar
  26. Richelson, E.,1977, Science,196:495CrossRefGoogle Scholar
  27. Rihmer, Z.,et al.,1982, Psychiat.Res.,6:197CrossRefGoogle Scholar
  28. Rihmer, Z., et al.,1983, Psychiat.Clin.,/in press/Google Scholar
  29. Saneto, R. P., et al.,1980, J.Neurochem.,34:1520PubMedCrossRefGoogle Scholar
  30. Saneto, R. P. and Perez-Polo, J. R.,1982, J.Neurosci.Res., 7:413PubMedCrossRefGoogle Scholar
  31. Schlesinger, H. R.,et al., 1979, Life Sci.,25:957PubMedCrossRefGoogle Scholar
  32. Szentistványi, I., 1978, Acta Biol.Acad.Sci.Hung.,29:101PubMedGoogle Scholar
  33. Szentistványi, I., and Janka, Z.,1979a,Biol.Psychiat., 14:973PubMedGoogle Scholar
  34. Szentistványi, I., and Janka, Z.,1979b, Psychiat.Res., 1:265CrossRefGoogle Scholar
  35. Szentistványi, I., et al.,1979a, Neurosci.Lett.,13:157PubMedCrossRefGoogle Scholar
  36. Szentistványi, I., et al.,1979b, Cell.Mol.Biol.,25:315Google Scholar
  37. Szentistványi, I., et al.,1980, Psychiat.Clin.,13:57Google Scholar
  38. Thomas, R. C.,et al.,1975, Nature/Lond./,258:754CrossRefGoogle Scholar
  39. Tosteson, D. C.,1981, Fed.Proc.,40:1429PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • István Szentistványi
    • 1
  • Zoltán Janka
    • 1
  1. 1.Department of Neurology and PsychiatryUniversity Medical School of SzegedSzegedHungary

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