LI Transport and the Psychoses

  • David L. Garver
  • Robert Hitzemann
  • Jack Hirschowitz


Previous studies have suggested that intracellular to extracellular concentrations of Li across RBC membranes (Li ratios) may be useful in identifying Li responsive affective illnesses. Though agreement is not unanimous, several authors have reported that higher Li ratios obtained in RBC exposed to Li in vitro or in vivo are associated with short term antimanic or antidepressant effects of Li, or with successful prophylaxis from affective episodes.Higher Li ratios, when determined by direct measurements of RBC as well as plasma Li,6-10 as well as impaired countertransport of Li from the RBC,11 appear to occur with a high frequency among affectively disordered patients who experience both manic and depressive episodes (bipolar disorder).


Major Depressive Disorder Lithium Concentration Borderline Personality Disorder Major Affective Disorder Schizophreniform Disorder 


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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • David L. Garver
    • 1
  • Robert Hitzemann
    • 1
  • Jack Hirschowitz
    • 1
  1. 1.University of Cincinnati College of MedicineCincinnatiUSA

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