LI Transport and the Psychoses
Previous studies have suggested that intracellular to extracellular concentrations of Li across RBC membranes (Li ratios) may be useful in identifying Li responsive affective illnesses. Though agreement is not unanimous, several authors have reported that higher Li ratios obtained in RBC exposed to Li in vitro or in vivo are associated with short term antimanic or antidepressant effects of Li, or with successful prophylaxis from affective episodes.Higher Li ratios, when determined by direct measurements of RBC as well as plasma Li,6-10 as well as impaired countertransport of Li from the RBC,11 appear to occur with a high frequency among affectively disordered patients who experience both manic and depressive episodes (bipolar disorder).
KeywordsMajor Depressive Disorder Lithium Concentration Borderline Personality Disorder Major Affective Disorder Schizophreniform Disorder
Unable to display preview. Download preview PDF.
- 9.Frazer A, Gottlieb J, Mendels J: Lithium ratio and clinical response in manic-depressive illness. Lancet 1:41–42, 1977.Google Scholar
- 14.Pandey GN, Sarkadi R, Gunn RB: Lithium transport pathways in human red cells. Psychopharm. Bull. 14:16–19, 1978.Google Scholar
- 16.Ost row DG, Trebesan M, Okonek A, Gibbons R, Cooper R, Davis JM: Sodium dependent membrane processes in major affective disorders, in Usdin E. and Hanin I. (eds.): Biological Markers in Psychiatry and Neurology, Pergamon Press, New York, 1982 pp. 153–168.Google Scholar
- 20.Pandey GN, Baker J, Chang S, Davis JM: Prediction of in vivo red cell/plasma lithium ratios in vitro methods. Clin. Pharm. Ther. 24:343–349, 1978.Google Scholar
- 26.American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, Third Edition (DSM-III), The American Psychiatric Association, Washington, DC, 1980.Google Scholar