Ten Years of Lithium Transport Research

  • David G. Ostrow


The occasion of an international symposium on the subject of lithium transport appropriately calls for a short review of some of the history behind this area of research. We are fortunate to have represented in this symposium a number of researchers from Europe and the United States, all of whom have been working for several years in this particular area of biological psychiatry. The communication that symposiums such as this provide for those of us working in this area will hopefully accelerate progress in understanding the relevance of lithium transport to the clinical practice of psychiatry. But first, a short review of the last ten years of lithium transport research. This will be a personal view of things reflecting primarily those events which have most influenced my own research directions.


Lithium Level Major Affective Disorder Human RBCs Plasma Lithium Lithium Transport 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    L. Lyttkens, U. Soderberg, and L. Wetterberg, Increased lithium erythrocyte-plasma ratio in manic-depressive psychosis, Lancet 1:40 (1973).PubMedCrossRefGoogle Scholar
  2. 2.
    J. Mendels, and A. Frazer, Intracellular lithium concentrations and clinical response: Towards a membrane theory of depression, J. Psychiatric Research 10:9–18 (1973).CrossRefGoogle Scholar
  3. 3.
    E. Dorus, G. N. Pandey, A. Frazier, and J. Mendels, Genetic determination of lithium ion distribution: I. An in Vitro monozygotic-dizygotic twin study, Arch. Gen. Psychiatry 31:463–465 (1974).PubMedCrossRefGoogle Scholar
  4. 4.
    E. Dorus, G. N. Pandey, R. Shaughnessy, M. Gaviria, E. Val, S. Erickson, J. M. Davis, Lithium transport across red cell membranes: A cell membrane abnormality in manic-depressive illness, Science 205:932–934 (1979).PubMedCrossRefGoogle Scholar
  5. 5.
    M. Haas, M. Schooler, and D. C. Tosteson, Coupling of lithium to sodium transport in human red cells, Nature 258:425–427 (1975).PubMedCrossRefGoogle Scholar
  6. 6.
    D. G. Ostrow, M. Trevisan, A. Okonek, R. Gibbons, R. Cooper, J. M. Davis, Sodium dependent membrane processes in major affective disorders, in: “Biological Markers in Psychiatry and Neurology,” I. Hanin and E. Usdin, eds., Pergamon Press, Oxford (1982).Google Scholar
  7. 7.
    G. N. Pandey, B. Sarkadi, M. Haas, R. B. Gunn, J. M. Davis, D. C. Tosteson, Lithium transport pathways in human red blood cells, J. Gen. Physiology 72:233–247 (1978).CrossRefGoogle Scholar
  8. 8.
    D. G. Ostrow, G. N. Pandey, J. M. Davis, S. S. Chang, D. C. Tosteson, Clinical study of lithium transport: A defect of phloretin-sensitive lithium transport in bipolar illness, Proceedings of the 1977 American Psychiatric Association Annual Meeting 130:152–153.Google Scholar
  9. 9.
    D. G. Ostrow, A. Okonek, S. Sparks, S. Flagel, R. Cooper, J. M. Davis, RBC lithium efflux in major affective disorders, Proceedings of the 1982 American Psychiatric Association Annual Meeting 135:180.Google Scholar
  10. 10.
    D. G. Ostrow, M. Canessa, S. Sparks, and J. M. Davis, Preservation of human erythrocytes for sodium-dependent lithium efflux rate measurements, Clin Chim. Acta 129:39–44 (1983).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • David G. Ostrow
    • 1
  1. 1.Departments of Psychiatry and Community Health & Preventive MedicineNorthwestern University Medical School VA Lakeside Medical CenterChicagoUSA

Personalised recommendations