The Serotonin-Noradrenaline Link-Hypothesis of Affective Disorders

  • Fridolin Sulser


Two main hypotheses of affective disorders have dominated research strategies in Biological Psychiatry: The catecholamine hypothesis (Schildkraut, 1965; Bunney and Davis, 1965) and the indolealkylamine or serotonin hypothesis (Coppen, 1972). These hypotheses are essentially deficiency hypotheses derived from studies on acute pharmacological effects elicited by a number of psychotropic drugs. The realization of the numerous inconsistencies in biochemical metabolic data derived from either plasma, urine or cerebral spinal fluid (Berger and Barchas, 1977) and of a number of shortcomings of the original biogenic amine hypotheses (Sulser, 1983), has triggered the search for alternate mechanisms.


Affective Disorder Antidepressant Treatment Cerebral Spinal Fluid Serotonergic Neuron Neuronal Uptake 
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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Fridolin Sulser
    • 1
  1. 1.Tennessee Neuropsychiatric InstituteVanderbilt University School of MedicineNashvilleUSA

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