The Serotonin-Noradrenaline Link-Hypothesis of Affective Disorders
Two main hypotheses of affective disorders have dominated research strategies in Biological Psychiatry: The catecholamine hypothesis (Schildkraut, 1965; Bunney and Davis, 1965) and the indolealkylamine or serotonin hypothesis (Coppen, 1972). These hypotheses are essentially deficiency hypotheses derived from studies on acute pharmacological effects elicited by a number of psychotropic drugs. The realization of the numerous inconsistencies in biochemical metabolic data derived from either plasma, urine or cerebral spinal fluid (Berger and Barchas, 1977) and of a number of shortcomings of the original biogenic amine hypotheses (Sulser, 1983), has triggered the search for alternate mechanisms.
KeywordsAffective Disorder Antidepressant Treatment Cerebral Spinal Fluid Serotonergic Neuron Neuronal Uptake
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- Berger, P.A. and Barchas, J.C., 1977, in: Psychopharmacology (Barchas, J.C., Berger, P.A., Ciaranello, R.D. and Elliot, G.R., eds.) pp. 151–173, Oxford University Press, New York, NY.Google Scholar
- Brunello, N., Chunag, D.M., Costa, E., 1982, Use of specific brain lesions to study the site of action of antidepressants. Adv. Biosc. 40: 141.Google Scholar
- Heydorn, W.E., Brunswick, D.J. and Frazer, A., 1982, Effect of treatment of rats with antidepressants on melatonin concentrations in the pineal gland and serum. Pharmacol. Exp. Ther. 222, 534.Google Scholar
- Shopsin, B., Friedman, E. and Gershon, S., 1975, The use of synthesis inhibitors in defining a role for biogenic amines during imipramine treatment in depressed patients. Psychopharmacol. Comm. 1, 239.Google Scholar
- Sulser, F., 1983, Mode of action of antidepressant drugs. J. Clin. Psychiat. 44 (5) Sec. 2, 14.Google Scholar
- Sulser, F., Gillespie, D.G. and Manier, D.H., 1983b, Adrenoceptor changes following repeated antidepressant treatment. Ann. N.Y. Acad. Sci. (in press).Google Scholar