Relevant Selectivity of Antidepressants

  • Stuart A. Montgomery


The amine deficit hypotheses of affective disorders have dominated research on the biochemical correlates of depression for the past twenty years. These hypotheses derive from the observation that certain drugs which deplete or block the action of monamines cause depressive symptomatology. Conversely certain compounds which have monoamine reuptake blocking properties, have marked antidepressant efficacy. The indoleamine hypothesis suggests that in depression there is a serotonin deficiency, and a reduction of neurotransmission associated with the disturbance in the availability of 5 hydroxytryptamine (5HT). The catecholamine hypothesis concentrates on disturbances in the noradrenergic system and suggests that reduced availability of noradrenaline (NA) is the significant factor.


Suicidal Behaviour Antidepressant Effect Uptake Inhibitor Noradrenergic System Antidepressant Efficacy 
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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Stuart A. Montgomery
    • 1
  1. 1.Academic Department of PsychiatrySt Mary’s HospitalLondon W2UK

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