ACTH and Cortisol Secretion in Cushing’s Disease and in Endogenous Depression: Indication of a Common Pathway?

  • Karl H. Voigt
  • Sabine Bossert
  • Stephan Bretschneider
  • Anette Bliestle
  • Horst L. Fehm


An impaired regulation of Cortisol secretion can be observed in patients suffering from one of two otherwise unrelated diseases: The hypothalamo-pituitary- dependent Cushing’s Syndrome and a subpopulation of major depressive illness. Among a number of different other disturbances of neuroendocrine regulations (Table 1) the cortisol-hypersecretion is the most important and the typical diagnostic sign for Cushing’s disease, and on the other hand, the most consistently observed hormonal dysregulation in endogenously depressed patients.


Depressive Symptom Pituitary Adenoma Cortisol Secretion ACTH Secretion Endogenous Depression 
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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Karl H. Voigt
    • 1
  • Sabine Bossert
    • 1
  • Stephan Bretschneider
    • 1
  • Anette Bliestle
    • 1
  • Horst L. Fehm
    • 1
  1. 1.Lab. for Neuroendocrinology and Dept.of PsychiatryUniversity of UlmUlmGermany

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