Sleep Structure and Neuroendocrine Rhythms

  • David J. Kupfer
  • David B. Jarrett


Current knowledge of affective disorders leads to the conclusion that these disorders entail dysfunction in many systems and do not reflect simply alterations in mood. Since many of the core symptoms of affective disorder represent changes in regulatory systems, investigators have frequently searched for biological correlates, possible markers of vulnerability and explored the interdependencies among aspects of biological and psychological functioning. Such an approach has yielded promising findings with regard to electroencephalographic (EEG) sleep abnormalities. Furthermore, the study of EEG sleep in affective states is now affording an opportunity to examine (among other biological variables) how aberrations in neuroendocrine pathways and circadian rhythms may be responsible for the various biological disturbances in depression.


Growth Hormone Depressed Patient Sleep Onset NREM Sleep Growth Hormone Peak 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • David J. Kupfer
    • 1
  • David B. Jarrett
    • 1
  1. 1.Department of PsychiatryUniversity of Pittsburgh School of Medicine, Western Psychiatric Institute and ClinicPittsburghUSA

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