The Comparative Effects of Indalpine and Amitriptyline on Saliva Production
Indalpine is a potent inhibitor of 5-Hydroxytryptamine uptake by central neurones (Le Fur et al., 1978) and has been shown in comparative clinical trials to be an effective antidepressant agent (Guelfi et al., 1981; Gerard et al., 1981).
KeywordsDepressive Patient Antidepressant Drug Salivary Volume Comparative Clinical Trial Anticholinergic Property
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- Bertram, U., Kragh-Sorensen, P., Rafaelsen, O., and Larsen, N.-E., Saliva secretion following long-term antidepressant treatment with nortriptyline controlled by plasma levels. Scand. J. Dent.Res., 87:58.Google Scholar
- Gérard, A., Clerc, G., Guibert, M., Robert, G., and Pagot, T., 1981, A double-blind investigation of a highly selective 5-HT uptake inhibitors Indalpine vs. Clomipramine in hospitalised depressive patients, presented at Eighth International Congress of Pharmacology, Tokyo. Ghose, K., Coppen, A., and Turner, P., 1976, Autonomic actions and interactions of mianserin hydrochloride (Org GB94) and amitriptyline in patients with depressive illnes, Psychopharmacol,, 49:201.Google Scholar
- Guelfi, J.D., Dreyfus, J.-F., Boyer, P., and Pichot, P., 1981, A double-blind controlled multicenter trial comparing indalpine with imipramine, presented at III World Congress of Biological Psychiatry, Stockholm.Google Scholar
- Kopera, H., 1978, Anticholinergic and blood pressure effects of mianserin, amitriptyline and placebo, Br.J.Clin. Pharmacol., 5 Suppl. 1:29S.Google Scholar
- Rafaelsen, O.J., Clemmesen, L., Lund, H., Mikkelsen, P.L., and Bolwig, T.G., 1980, Comparison of peripheral anticholinergic effects of antidepressants: dry mouth, Act. Psychiat. Scand., 63: Suppl. 290.Google Scholar
- von Knorring, L., 1981, Changes in saliva secretion and accommodation width during short-term administration of imipramine and zimelidine in healthy volunteers, Int. Pharmacopsychiat., 16:69.Google Scholar