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Brain Serotonin, Mood-Regulation and Aggression-Regulation

  • H. M. van Praag

Abstract

Rather consistently, the CSF post-probenecid concentration of 5-hydroxyindoleacetic acid (5-HIAA) — the main degradation product of 5-hydroxytryptamine (serotonin, 5-HT) — has been found to be lowered in a subgroup of patients suffering from the syndrome of vital (endogenous) depression (Review: van Praag,. The data on baseline 5-HIAA values in CSF are more controversial (Asberg et al., 1976; Koslow et al., 1983). Several groups have reported that the “subgroup” I referred to above was characterized by strong suicidal tendencies (Banki et al., 1981; Montgomery and Montgomery, 1982; van Praag, 1982; Banki and Arato, 1983). Low CSF 5-HIAA was in particular found in depressed patients who had attempted suicide with violent means (Asberg et al., 1976; Traskman et al., 1982). Subsequently low CSF 5-HIAA was likewise observed in what was called non-psychotic and non-depressed suicide attempters (Traskman et al., 1982). This prompted the hypothesis that disorders in central 5-HT are not so much related to depression as to suicidality irrespective of the nosological context in which this phenomenon occurred.

Keywords

Suicide Attempt Suicidal Behavior Personality Disorder Suicidal Patient Depression Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • H. M. van Praag
    • 1
  1. 1.Department of PsychiatryAlbert Einstein College of Medicine/Montefiore Medical CenterBronxUSA

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