Dynamic Hemispheric Imbalance in Schizophrenia
In a study of forty-eight unmedicated recent hospital admissions diagnosed as schizophrenic with the help of the Present State Examination (PSE) (Wing, Cooper and Sartorious, 1974) lateral asymmetries in electrodermal orienting responses were found in either direction (Gruzelier & Manchanda, 1982). Classification of patients according to the nature of the asymmetry and comparison of their symptoms and signs on the PSE and Brief Psychiatric Rating Scale (BPRS) (Overall & Gorham, 1962) delineated two syndromes, one representing positive symptoms and the other negative symptoms (see Gruzelier ‘Lateral imbalance and positive and negative symptoms’ in this collection). From consideration of the electrodermal lateral asymmetry, reciprocal interactions between the hemispheres in the control of arousal, and the character of the behaviour described in the syndromes, e.g. pressure of speech in one and restricted quantity of speech in the other, it was inferred that the positive syndrome reflected hemispheric imbalance in the direction of overactivation of the left hemisphere and the negative syndrome overactivation of the right hemisphere.
KeywordsNegative Symptom Brief Psychiatric Rate Scale Dichotic Listening Lateral Asymmetry Charing Cross Hospital
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- Coger, R.W. and Serafetinides, E.A. 1983, in: “Laterality and Psychopathology”, P. Flor-Henry and J.H. Grizelier, eds., Elsevier Science Publishers, Amsterdam, 225–248.Google Scholar
- Etevenon, P., Peron-Magnon, P., Campistron, D., Vordeaux, G. and Deniker, P., 1983, Differences in EEG asymmetry between patients with schizophrenia, in: Laterality and Psychopathology, P. Flor-Henry and J.H. Gruzelier, eds., Elsevier Science Publishers, Amsterdam, 269–290.Google Scholar
- Flor-Henry, P. and Gruzelier, J.H., eds., 1983, Laterality and Psychopatho1ogy, Elsevier Science Publishers, Amsterdam.Google Scholar
- Gruzelier, J.H., 1983a, A critical assessment and integration of lateral asymmetries in schizophrenia, in Hemisyndromes: Psychobiology, Neurology, Psychiatry, M. Myslobodsky, ed., Academic Press, London, 265–326.Google Scholar
- Gruzelier, J.H., 1983b, Conundrums in methods and theory in laterality research, in: Laterality and Psychopathology, P. Flor-Henry and J. Gruzelier, eds., Elsevier Science Publishers Amsterdam, 19–28.Google Scholar
- Gruzelier, J.H. and Flor-Henry, P., eds., 1979, Hemisphere Asymmetries of Function and Psychopathology, Elsevier, Amsterdam.Google Scholar
- Gruzelier, J.H., Jutai, J.W., Connolly, J.F. and Hirsch, S.R., 1984, Cerebral asymmetries in unmedicated schizophrenic patients in EEG spectra and their relation to clinical and autonomic parameters, Advances in Biological Psychiatry, S., Karger, Basel.Google Scholar
- Kinsbourne, M., 1980, A model of the ontogeny of cerebral organisation in non-right-handers, in: Neuropsychology of Left-Handedness,J. Herron, ed., Academic Press, New York.Google Scholar
- Rodin, E., Grisell, J. and Gottliev, J., 1968, Some electrographic subjects, in: Recent Advances in Biological Psychiatry, J. Wortis, ed., Plenum Press, New York.Google Scholar
- Wing, J.K., Cooker, J.E. and Sartorius, N., 1974, in. The Measurement and Classification of Psychiatric Symptoms, Cambridge Univ. Press, London and New York.Google Scholar