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PET Studies on Brain Energy Metabolism and Dopamine Receptors in Schizophrenic Patients and Monkeys

  • G. Sedvall
  • G. Blomqvist
  • T. DePaulis
  • E. Ehrin
  • L. Eriksson
  • L. Farde
  • T. Greitz
  • C. G. Hedström
  • D. H. Ingvar
  • J.-E. Litton
  • J. L. G. Nilsson
  • S. Stone-Elander
  • L. Widén
  • F.-A. Wiesel
  • G. Wik

Abstract

Since about two years, the PET-scan group at the Karolinska institute in Stockholm has been engaged in analysing various aspects of brain function in schizophrenic patients using the PET-scan technique. Most studies performed so far have concerned the use of 11-C-labelled glucose to study brain energy metabolism (Blomqvist et al., 1983). The studies reported in a preliminary form in this communication had the following objectives: (1) To compare regional brain net uptake of 11-C in schizophrenic patients and healthy volunteers after intravenous injection of 11-C-glucose. (2) Examine variability of metabolic data obtained from two measurements in healthy volunteers. (3) Examine the effect of a standardized neuroleptic treatment (sulpiride) on regional glucose metabolism in schizophrenic patients. (4) Explore the possibility to visualize brain dopamine receptors in monkeys using 11-C-labelled substituted benzamides.

Keywords

Dopamine Receptor Schizophrenic Patient Caudate Nucleus Cynomolgus Monkey Brodmann Area 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • G. Sedvall
    • 1
  • G. Blomqvist
    • 1
  • T. DePaulis
    • 1
  • E. Ehrin
    • 1
  • L. Eriksson
    • 1
  • L. Farde
    • 1
  • T. Greitz
    • 1
  • C. G. Hedström
    • 1
  • D. H. Ingvar
    • 1
  • J.-E. Litton
    • 1
  • J. L. G. Nilsson
    • 1
  • S. Stone-Elander
    • 1
  • L. Widén
    • 1
  • F.-A. Wiesel
    • 1
  • G. Wik
    • 2
  1. 1.Departments of Psychiatry and Psychology, Clinical Neuro-Neurophysiology and Neuroradiology at the Karolinska InstituteKarolinska PharmacyStockholm, SödertäljeSweden
  2. 2.Astra LäkemedelSödertäljeSweden

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