Advertisement

A Study of Epilepsy and Interictal Psychosis Using the Oxygen-15 Inhalation Technique and Position Emission Tomography

  • B. Gallhofer
  • M. R. Trimble
  • R. S. J. Frackowiak
  • R. J. S. Wise
  • T. Jones

Abstract

There are new several studies of positron emission tomography in epilepsy, and virtually all have used fluoro-deoxyglucose as the preferred method of investigation. They have mainly examined selected patients undergoing evaluation for consideration of temporal lobe surgery for intractable seizures. Similarly, the published data using this technique in schizophrenia have also used glucose uptake to assess metabolism. The Hammersmith group have developed the technique using oxygen-15 and positron emission tonography for the measurement of regional cerebral blood flow (rCBF), and the regional oxygen extraction fraction (rOER), which permits the calculation of regional oxygen metabolism (rCMRO2), (Frackcwiak, Lenzi, Jones and Heather 1980). In this paper we presentdata on a group of patients with epileptic psychosis.

Keywords

Temporal Lobe Epilepsy Partial Seizure Regional Cerebral Blood Flow Partial Epilepsy Psychotic Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bernardi S, Trimble MR, Frackcwiak RJS, Wise RJS, and Jones T, (1983), An interictal study of partial epilepsy using positron emission tomography and the oxygen-15 inhalation technique. J Neurol Neurosurg Psychiat 46 473–477.PubMedCrossRefGoogle Scholar
  2. Di Lisi LE, Buchsbaum MS, Irving CA, Dcwling S, Johnson J, Holcorib HH, Kessler R, and Boroncw J, (1983),Clinical correlates of PET in schizophrenia. New Research Abstracts. American Psychiatric Association Annual Meeting May 1983 NR49.Google Scholar
  3. Engel J, Kuhl DE, Phelps ME, and Mazziota JC, (1982), Interictal Cerebral Glucose Metabolism in partial epilepsy and its relation to EEG changes. Ann Neurol 12: 512–517.Google Scholar
  4. Engel J, Brcwm WJ, Kuhl DE, Phelps ME, Mazziota JC, and Crandall PH,(1982), Pathological findings underlying focal tenporal lobe hyponetabolism in partial epilepsy. Ann Neurol 12:518–528PubMedCrossRefGoogle Scholar
  5. Engel J, Kuhl DE, Phelps ME, and Crandall PH, (1982), Comparative localisation of epileptic foci in partial epilepsy by PCT and EEG. Ann Neurol 12:529–537.PubMedCrossRefGoogle Scholar
  6. Frackcwiak RS, Lenzi GL, Jones T, and Heather JD, (1980), Quantitative measurement of regional cerebral blood flew and oxygen metabolism in man using 150 and positron emission tonography. J Corput Assist Tonogr 4:727–736.CrossRefGoogle Scholar
  7. Hill D, (1953), Psychiatric disorders of epilepsy. Med Press 229:473–475.Google Scholar
  8. Perez MM, and Trimble MR, (1980), Epileptic Psychosis — diagnostic canparison with process schizophrenia. Brit J Psychiat 137:245–249.PubMedCrossRefGoogle Scholar
  9. Pond DA, (1957), Psychiatric aspects of epilepsy. J Ind Med Prof 3:1441–1451.Google Scholar
  10. Slater E, and Beard AW, (1963), The schizcphrenia-like psychoses of epilepsy. Brit J psychiat 109:95–150.PubMedCrossRefGoogle Scholar
  11. Stevens JR, (1982), Risk factors for psychopathology in individuals with epilepsy. In: Tenporal Lobe Epilepsy, Mania, and Schizophrenia and the Limbic system, ed Koella WP and Trimble MR pp56–80. Basel Karger.Google Scholar
  12. Trimble MR, (1982), The interictal psychoses of epilepsy. In: Psychiatric Aspects of Neurologic Disease, ed Benson DF and Blumer D pp 75–91 New York Grune and Stratton.Google Scholar
  13. Trimble MR and Perez MM, (1982) The phenomenology of the chronic psychoses of epilepsy. In: Tenporal lobe epilepsy, Mania, and Schizophrenia and the Limbic System, ed Koella WP and Trimble MR pp98–105. Basel Karger.Google Scholar
  14. Wing JK, Cooper JE,and Sartorius N, (1974), The description and classification of psychiatric syirptcms. London Cambridge University Press.Google Scholar

Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • B. Gallhofer
    • 1
  • M. R. Trimble
    • 1
  • R. S. J. Frackowiak
    • 1
  • R. J. S. Wise
    • 1
  • T. Jones
    • 1
  1. 1.National Hospital, Queen Square and the MRC Cyclotron UnitHammersmith HospitalLondonUK

Personalised recommendations