Chronobiology of Affective Disorders: Alterations in Circadian Secretion of Pituitary and Pineal Hormones in Bipolar and Unipolar Depression

  • Julien Mendlewicz
  • D. P. Linkowski


Affective disorders are characterized by episodic alterations in mood and physiological functions indicating that these illnesses may be considered as biological clock disorders. This paper reviews some of the data on biological rhythm disturbances in affective illness with special reference to circadian alterations in secretion of pituitary and pineal hormones and disturbances in sleep EEG parameters in depressive illness.


Circadian Rhythm Depressed Patient Slow Wave Slow Wave Sleep Bipolar Patient 
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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Julien Mendlewicz
    • 1
  • D. P. Linkowski
    • 1
  1. 1.Department of PsychiatryErasme Hospital University Clinics of Brussels, Free University of BrusselsBrusselsBelgium

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