Pharmacoendocrinology and Its Clinical Relevance

  • Gregor Laakmann


Studies of effects of a variety of psychotropic drugs on pituitary hormone secretion are based on the theory that such drugs affect the functions of aminergic neurons, which in turn can influence the effects of the pituitary hormones. The three following sections include primarily our own results on first, the effect of psychotropic drugs on pituitary hormone secretion, second, the effect of receptor blockers on the changes in pituitary hormone secretion due to psychotropic drugs and third, the GH stimulating properties of DMI in depressive patients.


Growth Hormone Luteinizing Hormone Psychotropic Drug Pituitary Hormone Cortisol Secretion 
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  1. Laakmann, G., 1980, Beeinflussung der Hypophysenvorder- lappen-Hormonsekretion durch Antidepressiva bei gesunden Probanden, neurotisch und endogen depressiven Patienten. Nervenarzt 51:725.PubMedGoogle Scholar
  2. Laakmann, G., Treusch, J., Schmauss, M., Schmitt, E., Treusch, U., 1982a, Comparison of growth hormone stimulation induced by desimipramine, diazepam and metaclazepam in man. Psychoneuroendocrinalogy 7: 141.CrossRefGoogle Scholar
  3. Laakmann, G., Treusch, J., Eichmeier, A., Schmauss, M., Treusch, U., Wahlster, U., 1982b, Inhibitory effect of phentolamine on diazepam-induced growth hormone secretion and lack of effect of diazepam on prolactin secretion in man. Psychoneuroendocrinology 7:135.PubMedCrossRefGoogle Scholar
  4. Laakmann, G., Schoen, H.W., Wittman, M., and Zygan, K., 1983, Effect of receptor blockers on the desimi- pramine-induced stimulation of growth hormone and prolactin in man. in: E. Endroeczi et al., eds., “Integrative Neurohumoral Mechanisms”, Elsevier/ North Holland Biomedical Press, Amsterdam.Google Scholar
  5. Laakmann, G., Gugath, M., Kuss, H.-J., and Zygan, K., in press, Comparison of growth hormone and prolactin stimulation induced by chlorimipramine and desimi- pramine in man in connection with chi orimipramine metabolism.Google Scholar
  6. Langer, G., 1979, The “Prolactin-model” for the study of the pharmacodynamics of neuroleptic drugs in man. in: E.E. Müller, A. Agnoli, eds., “Neuroendocrine Correlates in Neurology and Psychiatry,” Elsevier/North-Holland Biomedical Press, Amsterdam New York-Oxford.Google Scholar
  7. Martin, J.B., Reichlin, S. and Brown, G.M., 1977, “Clinical Neuroendocrinology,” Davis, Philadelphia.Google Scholar
  8. Mesters, P., Linkowski, P.,Hoffmann, G.,Charles, G.,Kerkhofs, M., Decoster, C., Vanderelst, M., and Mendlewicz, J., 1983, Growth hormone stimulation by desipramine in depression, in: Abstracts of the VII World Congress of Psychiatry, Vienna.Google Scholar
  9. Sawa, Y., Odo, S., and Nakazawa, T., 1982, Growth hormone secretion by tricyclic and non-tricyc1ic antidepressants in healthy volunteers and depressives, in: S.Z. Langer et al., eds., “New Vistas in Depression. Advances in the Biosciences,” Vol. 40, Pergamon Press, Oxford-New York-Toronto-Sydney- Paris-Frankfurt.Google Scholar

Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Gregor Laakmann
    • 1
  1. 1.Psychiatrische Klinik der Universität MünchenMunich 2F.R. Germany

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