Advertisement

Neuroleptic-Like Activity of Estrogens

  • Thérèse Di Paolo
  • Paul Bédard
  • Fernand Labrie

Abstract

Tardive dyskinesias are more frequent in postmenopausal women than in men (Kane, 1982). Estrogens, when administered to parkinsonian patients can decrease Dopa-induced dyskinesia and in some cases increase the signs of parkinsonism (Bédard et al., 1979). The same antidyskinetic effect is observed in patients suffering from tardive dyskinesia (Bédard et al., 1979; Villeneuve et al., 1980). These clinical observations point to neuroleptic-like activity of estrogens at the level of the striatum. The following experiments have been able to confirm these clinical results.

Keywords

Prolactin Level Tardive Dyskinesia Estradiol Treatment Plasma Prolactin Level Haloperidol Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bédard, P.J., Boucher, R., and Larochelle, L., 1982, Experimental tardive dyskinesia, Prog. Neuro-Psychopharmacol. & Biol. Psychiatr., 6: 551.CrossRefGoogle Scholar
  2. Bédard, P., Boucher, R., Di Paolo, T., and Labrie, F., 1983, Bipha sic effect of estradiol and domperidone on lingual dyskinesia in monkeys, Exp. Neurol., 82: in press.Google Scholar
  3. Bédard, P.J., Langelier, P., Dankova, J., Villeneuve, A., Di Paolo T., Barden, N., Labrie, F., Boissier, J.R., and Euvrard, C., 1979, Estrogens, progesterone and the extrapyramidal system, Adv. Neurol., 24:411.Google Scholar
  4. Di Paolo, T., Carmichael, R., Labrie, F., and Raynaud, J.P., 1979, Effects of estrogens on the characteristics of [3H]spiroperidol and [3H]RU24213 binding in rat anterior pituitary gland and brain, Mol. Cell. Endocrinol., 16:99.PubMedCrossRefGoogle Scholar
  5. Di Paolo, T., Poyet, P., and Labrie, F., 1981, Effect of chronic estradiol and haloperidol treatment on striatal dopamine receptors Eur. J. Pharmacol., 73:105.PubMedCrossRefGoogle Scholar
  6. Di Paolo, T., Poyet, P., and Labrie, F., 1982, Effect of prolactin and estradiol on rat striatal dopamine receptors, Life Sci., 31, 2921.PubMedCrossRefGoogle Scholar
  7. Gordon, J., 1980, Modulation of apomorphine-induced stereotypy by estrogen: time course and dose-response, Brain Res. Bull., 5: 679.PubMedCrossRefGoogle Scholar
  8. Joyce, J.N., Smith, R.L., and Van Hartesveld, 1982, Estradiol suppresses, then enhances intracaudate dopamine-induced contralateral deviation, Eur. J. Pharmacol., 81:117.PubMedCrossRefGoogle Scholar
  9. Kane, J.M. and Smith, J.M., 1982, Tardive dyskinesia, Arch. Gen. Psychiatry, 39:473.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Thérèse Di Paolo
    • 1
  • Paul Bédard
    • 2
  • Fernand Labrie
    • 1
  1. 1.Department of Molecular EndocrinologyCHULQuebecCanada
  2. 2.Neurobiology Laboratory, Dept of AnatomyLaval UniversityQuebecCanada

Personalised recommendations