Neuroleptic-Like Activity of Estrogens

  • Thérèse Di Paolo
  • Paul Bédard
  • Fernand Labrie


Tardive dyskinesias are more frequent in postmenopausal women than in men (Kane, 1982). Estrogens, when administered to parkinsonian patients can decrease Dopa-induced dyskinesia and in some cases increase the signs of parkinsonism (Bédard et al., 1979). The same antidyskinetic effect is observed in patients suffering from tardive dyskinesia (Bédard et al., 1979; Villeneuve et al., 1980). These clinical observations point to neuroleptic-like activity of estrogens at the level of the striatum. The following experiments have been able to confirm these clinical results.


Prolactin Level Tardive Dyskinesia Estradiol Treatment Plasma Prolactin Level Haloperidol Treatment 
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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Thérèse Di Paolo
    • 1
  • Paul Bédard
    • 2
  • Fernand Labrie
    • 1
  1. 1.Department of Molecular EndocrinologyCHULQuebecCanada
  2. 2.Neurobiology Laboratory, Dept of AnatomyLaval UniversityQuebecCanada

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