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Oestrogen Modulation of Dopamine Receptors: Autoreceptor Implication for Antidepressant Activity

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Biological Psychiatry, Higher Nervous Activity
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Abstract

Biochemical and pharmacological evidence in animals indicates that oestrogens are capable of substantially modulating postsynaptic dopamine (DA) receptor sensitivity (1,2). Recent physiological data, indicating that oestrogens significantly attenuate the ability of apomorphine to inhibit the firing activity of type B dopamine neurons in the rat substantia nigra, suggest that these hormones may also induce a subsensitivity of DA autoreceptors (3).

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References

  1. C. Euvrard, C. Oberlander and J.R. Boissier, “Antidopaminergic effect of estrogens at the striatal level”, J.Pharmacol.Exp. 214: 179 (1980).

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  2. J.H. Gordon, R.A. Gorski, R.L. Borison, B.I. Diamond, “Postsynaptic efficacy of dopamine: possible suppression by estrogen”, Pharmacol.Biochem.Behav., 12: 515 (1980).

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  3. L.A. Chiodo and A.R. Caggiula, “Alterations in basal firing rate and autoreceptor sensitivity of dopamine neurons in the substantia nigra following acute and extended exposure to estrogen”, Eur.J.Pharmacol., 67: 165 (1980).

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  4. P. Piccardi, F. Bernardi, Z. Rossetti, G.U. Corsini, “Effect of estrogens on dopamine autoreceptors in male rats”, Eur.J.Pharmacol. 91 (In Press) (1983).

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  5. M.P. Piccardi, F. Bernardi, A. Bocchetta, G.U. Corsini, “Estrogen modulation of dopaminomimetic actions: Implications for autoreceptor regulation”, In: Lisuride and other dopamine agonists, Eds. D.B. Calne et al., Raven Press, New York, 1983, pp.55–64.

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© 1985 Springer Science+Business Media New York

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Piccardi, M.P., Del Zompo, M., Meloni, M., Corsini, G.U. (1985). Oestrogen Modulation of Dopamine Receptors: Autoreceptor Implication for Antidepressant Activity. In: Pichot, P., Berner, P., Wolf, R., Thau, K. (eds) Biological Psychiatry, Higher Nervous Activity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8329-1_34

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  • DOI: https://doi.org/10.1007/978-1-4684-8329-1_34

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8331-4

  • Online ISBN: 978-1-4684-8329-1

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