Advertisement

Oestrogen Modulation of Dopamine Receptors: Autoreceptor Implication for Antidepressant Activity

  • M. P. Piccardi
  • M. Del Zompo
  • M. Meloni
  • G. U. Corsini

Abstract

Biochemical and pharmacological evidence in animals indicates that oestrogens are capable of substantially modulating postsynaptic dopamine (DA) receptor sensitivity (1,2). Recent physiological data, indicating that oestrogens significantly attenuate the ability of apomorphine to inhibit the firing activity of type B dopamine neurons in the rat substantia nigra, suggest that these hormones may also induce a subsensitivity of DA autoreceptors (3).

Keywords

Dopamine Neuron Firing Activity Hormone Administration Estradiol Benzoate Dihydroxyphenylacetic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    C. Euvrard, C. Oberlander and J.R. Boissier, “Antidopaminergic effect of estrogens at the striatal level”, J.Pharmacol.Exp. 214: 179 (1980).Google Scholar
  2. 2.
    J.H. Gordon, R.A. Gorski, R.L. Borison, B.I. Diamond, “Postsynaptic efficacy of dopamine: possible suppression by estrogen”, Pharmacol.Biochem.Behav., 12: 515 (1980).PubMedCrossRefGoogle Scholar
  3. 3.
    L.A. Chiodo and A.R. Caggiula, “Alterations in basal firing rate and autoreceptor sensitivity of dopamine neurons in the substantia nigra following acute and extended exposure to estrogen”, Eur.J.Pharmacol., 67: 165 (1980).PubMedCrossRefGoogle Scholar
  4. 4.
    P. Piccardi, F. Bernardi, Z. Rossetti, G.U. Corsini, “Effect of estrogens on dopamine autoreceptors in male rats”, Eur.J.Pharmacol. 91 (In Press) (1983).Google Scholar
  5. 5.
    M.P. Piccardi, F. Bernardi, A. Bocchetta, G.U. Corsini, “Estrogen modulation of dopaminomimetic actions: Implications for autoreceptor regulation”, In: Lisuride and other dopamine agonists, Eds. D.B. Calne et al., Raven Press, New York, 1983, pp.55–64.Google Scholar

Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • M. P. Piccardi
    • 1
  • M. Del Zompo
    • 1
  • M. Meloni
    • 1
  • G. U. Corsini
    • 1
  1. 1.Dept. of Clinical PharmacologyUniversity of CagliariCagliariItaly

Personalised recommendations