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Decreased CSF Norepinephrine and Monoamine Metabolites in Schizophrenic Patients with Brain Atrophy as Shown with CT Scans

  • Daniel P. van Kammen
  • Lee S. Mann
  • Mika Scheinin
  • Philip T. Ninan
  • Welmoet B. van Kammen
  • Markku Linnoila

Abstract

Spinal fluid levels of homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), 3-4 dihydroxyphenylacetic acid (DOPAC), norepinephrine (NE) and 3-methoxy-4-hydroxyphenylglycol (MHPG) were evaluated in off-medication chronic schizophrenic patients with (N=B) and without (N=43) evidence of brain atrophy of computerized tomography (CT) scans. Patients with brain atrophy showed significantly lower levels of these spinal fluid constituents except MHPG. These CSF findings support the proposed subdivision of schizophrenia with and without brain atrophy. Future CSF studies need to take brain atrophy into account among variables as diet, age, sex, sleep (hours), drug conditions, clinical state, anxiety and activity.

Keywords

Computerize Tomography Spinal Fluid Brain Atrophy Indoleacetic Acid Drug Condition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Daniel P. van Kammen
    • 1
  • Lee S. Mann
    • 1
  • Mika Scheinin
    • 1
  • Philip T. Ninan
    • 1
  • Welmoet B. van Kammen
    • 1
  • Markku Linnoila
    • 1
  1. 1.Western Psychiatric Institute and ClinicUniversity of Pittsburgh, School of MedicinePittsburghUSA

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