Decreased CSF Norepinephrine and Monoamine Metabolites in Schizophrenic Patients with Brain Atrophy as Shown with CT Scans
Spinal fluid levels of homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), 3-4 dihydroxyphenylacetic acid (DOPAC), norepinephrine (NE) and 3-methoxy-4-hydroxyphenylglycol (MHPG) were evaluated in off-medication chronic schizophrenic patients with (N=B) and without (N=43) evidence of brain atrophy of computerized tomography (CT) scans. Patients with brain atrophy showed significantly lower levels of these spinal fluid constituents except MHPG. These CSF findings support the proposed subdivision of schizophrenia with and without brain atrophy. Future CSF studies need to take brain atrophy into account among variables as diet, age, sex, sleep (hours), drug conditions, clinical state, anxiety and activity.