Morphological Backgrounds of Pathochemical Studies in Major Psychoses

  • Kurt Jellinger

Abstract

The morphological substrates of major psychoses are controversial. While structural changes in the brain are commonly present in dementias and organic psychoses, no consistent deficits have been substantiated in schizophrenia and other psychoses that are associated with a variety of pathochemical changes. While a wide variety of structural and cytological changes described in schizophrenic brains1 are considered by most authors as nonspecific coincidental or agonal changes unrelated to the primary psychbsis2,3 both neuroradiological4-6 and neuropathological studies suggest that structural deficits including brain atrophy and neuronal loss and gliosis in some brain areas may occur in some subsets of schizophrenia, mainly in chronic cases and defect states akin to the chronic type II syndrome of negative symptoms6. A series of neuroradiological, CBF and histological data have been believed to indicate an “anatomic al locus of the pathology of schizophrenia” that has been tentatively related to disorders of subcorticocortical, thalamic and mesolimbic systems1,6.

Keywords

Dopamine Leukemia Pneumonia Dementia Schizophrenia 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    J.R. Stevens, Neuropathology of schizophrenia, Arch.Psychiat.(Chic.) 39,1131(1982)CrossRefGoogle Scholar
  2. 2.
    J.A.N. Corsellis, Psychoses of obscure pathology, In: Greenfield’s Neuropathology, W. Blackwood, J.A.N. Corsellis, eds, E. Arnold, London (1976).Google Scholar
  3. 3.
    K. Jellinger, Zur Neuropathologie schizophrener Psychosen, Curr. Top. Neuropath. 6, 85(1980).Google Scholar
  4. 4.
    G. Gross, G. Huber, R.L. Schüttler, CT studies on schizophrenic diseases. Arch.Psychiat.Nervenkrankh. 231, 519(1982)CrossRefGoogle Scholar
  5. 5.
    D.R. Weinberger, L.E. DeLisi, G.P. Perman, CT in schizophreniform disorder and other acute psychiatric disorders. Arch.gen.Psych. 39, 778(1982)CrossRefGoogle Scholar
  6. 6.
    J.T. Crow, Two syndromes in schizophrenia. TINS 5, 351 (1982).Google Scholar
  7. 7.
    P. Riederer, K. Jellinger, Biochemie und Morpholo gie der Schizophrenie. Schwerpunktmed. 5, 32(1982)Google Scholar
  8. 8.
    E.J. Colon, Quantitative cytoarchitectonics of the human cortex in schizophrenic dementia. Acta neuropath. (Berl.) 20, 1 (1972)CrossRefGoogle Scholar
  9. 9.
    R. Dom, J.De Saedeleer, Quantitative cytometric analysis in catatonic schizophrenia. Abstr. 3rd World Congr.Biol.Psychiat.Stockholm 1982.Google Scholar
  10. 10.
    T. Miyakawa, S. Sumiyoshi, M.Deshimaru, Electron microscopic study on schizophrenia. Acta neuropath. (Berl.) 20,67 (1972).CrossRefGoogle Scholar
  11. 11.
    L.D.Hankhoff, N.S. Peress, Neuropathology of the brain stem in psychiatric disorders. Biol. Psychiat. 16, 945(1981)Google Scholar
  12. 12.
    K. Buttlar-Brenatno, Pathohistologische Feststel lungen am Basalkern Schizophrener. J.Nerv.Ment. Pis. 116, 646(1952)CrossRefGoogle Scholar
  13. 13.
    T. Arendt, Y. Bigl, A. Arendt, A. Tennstedt, Loss of neurons in the nucleus basalis of Meynert in Alzheimer’s disease, paralysis agitans and Korsakoff disease. Acta neuropath. (Berl.) 61(1983)Google Scholar
  14. 14.
    J.T. Doyle, D. Price, M.R. DeLong, Alzheimer’s disease: a disorder of cortical cholinergic innervation. Science 219, 1184(1983).CrossRefGoogle Scholar
  15. 15.
    E.D. Bird, E.G.S. Spokes, L.L. Iversen, Increased dopamine concentration in limbic areas of patients with schizophrenia. Brain 102, 347(1979).PubMedCrossRefGoogle Scholar
  16. 16.
    J.P. Feighner, E. Robins, S. Guze, R.A. Woodruff, G. Winokur, Diagnostic criteria for use in psychiatric reserach. Arch.gen.Psychiat. 26, 57 (1972)PubMedCrossRefGoogle Scholar
  17. 17.
    D.M. Bowen, C.B. Smith, P. White, Chemical pathology of organic dementias. Brain 100, 397(1977).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Kurt Jellinger
    • 1
  1. 1.L. Boltzmann-Institute of Clinical NeurobiologyLainz-HospitalViennaAustria

Personalised recommendations