Metabolic Disturbances in Psychiatric Disorder: The Question of Diagnostic Specificity
An increasing number of indirect neurochemical markers have been proposed to reflect CNS biological dysfunctions underlying some psychiatric disorders in man. CSF amine metabolites were often reported to be decreased in depression, but several later studies contradicted; there are some excellent reviews covering this subject1,2. In contrast, more recent works seem to support the view that CSF biochemical parameters /concentration of HVA, 5HIAA, MHPG, etc./ are more closely correlated with syndrome subtypes, symptoms or other physical or psychological variables than with the clinical diagnosis itself3-5. Some “elementary” symptoms were already found to be related to certain CSF metabolites: motor activity to HVA6, anxiety and insomnia to 5HIAA7, suicide and aggression to 5HIAA and MHPG2,8,9. However, the study of isolated symptoms in relationship with biochemical alterations has usually been confined to a limited number of clinical disorders4,10.
KeywordsAlcohol Dependence Suicidal Thought Adjustment Disorder Amine Metabolite Comprehensive Psychopathological Rating Scale
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- 1.H.M. Van Praag, “Depression and Schizophrenia, a Contribution on their Chemical Pathologies.” Spectrum, New York /1977/Google Scholar
- 2.M. Asberg, and L. Bertilsson, Serotonin in depressive illness, studies of CSF 5KIAA, in: “Neuro-Psychopharmacology,” B. Saletu, P. Berner, L.E. Hollister, eds., Pergamon, Oxford /1979/Google Scholar
- 4.H. Agren, Biological markers in major depressive disorders. Thesis, Uppsala /1981/Google Scholar
- 5.M. Asberg, L. Bertilsson, E. Rydin, D. Schalling, P. Thoren, and L. Traskman, Monoamine metabolites in CSF in relation to depressive illness, suicidal behaviour and personality, in: “Recent Advances in Neuro-Psychopharmacclogy,” B. Angrist, G.D. Burrows, M. Lader, O. Lingjoerde, G. Sedrau, D. Wheatley, eds., Pergamon, Oxford /1981/Google Scholar
- 8.G.L. Brown, J.C. Ballenger, M.D. Minichiello, and P.K. Goodwin, Human aggression and its relationship to cerebrospinal fluid 5HIAA, MHPG and HVA, in: “Psychopharmacology of Aggression,” M. Sandler, ed, Raven, New York /1979/Google Scholar
- 9.C.M. Banki, and M. Arato, Amine metabolites and neuroendocrine responses related to depression and suicide J.Affect,Disord /in. press/Google Scholar
- 10.C.M. Banki, Evidence of disturbance of monoamines in depression, in: “Management of Depression with Monoamine Precursors,” H.M. Van Rraag, J. Mendlewitz, eds., Karger, Basel /in press/Google Scholar
- 11.G. Curzon., B.D. Kantamaneni, P.Van Boxel, and P.K. Gillman, Substances related to serotonin in plasma and in lumbar and ventricular fluids of psychiatric patients. Acta psychiat. scand. suppl. 280:3 /1980/Google Scholar