Destructive Interactions Between Murine Macrophages, Tumor Cells, and Antibodies of the IgG2a Isotype
Accumulated evidence from several laboratories indicates that murine antibodies of the IgG2a isotype are particularly potent in producing inhibition and destruction of murine tumors growing in situ (1–3) and of human tmors implanted in nude mice (4). Such antibodies can interact with macrophages to kill tumor cells in vitro (4,5), and macrophages have been implicated in the tumor destruction induced by IgG2a antibodies in vivo (3,4,5,6). Given this evidence, we examined the lytic interrelationships between macrophages, tumor cells, and antitumor antibodies of the IgG2a isotype in some detail. We here summarize the evidence that this interaction results in a potent antibody-dependent cell-mediated cytotoxicity (ADCC) reaction, distinct in several regards from that usually effected by macrophages and pertinent to the destruction of growing neoplasms in vivo.
KeywordsMurine Macrophage Direct Lysis Antitumor Antibody Murine Mammary Adenocarcinoma Destructive Interaction
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