The Cell Biology of Tumor Cell Capture by Activated Macrophages
Mononuclear phagocytes represent an important cellular element in the destruction of emerging and established neoplasms in vivo (1). Over the past several years, several distinct types of tumor cell kill by macrophages have been identified and examined in detail (2). This multiplicity of destructive modes is not surprising, since mononuclear phagocytes possess over 30 defined receptors on their surface and secrete over 75 distinct molecules (3). At least 10 of these receptors and over 20 of these molecules are potential candidates for recognizing and destroying tumor cells respectively (2,3). Thus, a general paradigm for cellular kill by macrophages has emerged: recognition of a tumor cell by one or more receptors, transduction of a signal from these receptors, and secretion of one or more injurious molecules to effect target injury and destruction (2,3). This paradigm is consistent with data available in the three systems of macrophage-mediated destruction of tumor cells now studied in some detail. In all three, kill may be divided into two stages: a) recognition and b) lysis (TABLE 1).
KeywordsMononuclear Phagocyte Selective Binding Phorbol Myristate Acetate Calcium Ionophore A23187 Inflammatory Macrophage
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