Cell Surface Thiols, Methylation, and Complement-Like Components are Involved in the Early Events of CML Whereas Proteases Participate in the Later, Ca++-Dependent Events

  • Doug Redelman
  • Dorothy Hudig
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 187)


The long term goals of our work are to define the chemical and metabolic functions required for cell-mediated lysis, to identify the molecules that participate in the lytic process, and ultimately, to characterize how the molecules mediate the required functions. We have used both murine cytotoxic T lymphocytes (CTL) and human natural killer (NK) cells as model systems. The data to be summarized here were obtained principally with the murine CTL system.


Protease Substrate Tyrosine Methyl Ester Tyrosine Methyl Ester Tyrosine Ethyl Ester Human Natural Killer Activity 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Doug Redelman
    • 1
  • Dorothy Hudig
    • 1
  1. 1.Department of MicrobiologyUniversity of Nevada-RenoRenoUSA

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