Evidence for the Molecular Dissociation of Binding and Post-Binding Functions in Cytotoxic T Lymphocytes
The interaction between the cytotoxic T lymphocyte (CTL) and its target cell has been a model of immune cellular interaction for several years because of the relatively short time course between the actual receptor-ligand interaction and its functional expression in target cell lysis. The nature of the lethal event within the target remains unclear but recent experiments from our laboratory and others have suggested that CTL mediated lysis involves not only the production of an osmotic lesion in the plasma membrane but also rapid changes in nuclear and chromatin structure (see ref. #1 for review). This nuclear lesion distinguishes CTL mediated lysis from cell death mediated by Ab+C1 or hypotonic shock.
KeywordsLytic Activity Mixed Lymphocyte Culture Lytic Process Lytic State Weekly Stimulation
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