Cell-Cell Contact Proteins in Antigen-Specific and Antigen-Nonspecific Cellular Cytotoxicity
The lysis of target cells (TCs) by cytotoxic T lymphocytes (CTLs) is probably mediated by proteins in the CTL plasma membrane. While the physiology of CTL-TC interactions has been described in detail (1-3), little is known about the molecular organization of the CTL surface membrane in the contact area of CTL-TC conjugates. The ability of certain alloantisera and monoclonal antibodies to inhibit CTL-mediated cytotoxicity in the absence of complement has served to identify functionally important CTL cell surface molecules: Lyt-2 (4,5) and lymphocyte function-associated antigens (LFA) (6,7). A similar approach has suggested that Lyt 5, also called T200, participates in the lytic mechanism of natural killer (NK) cells (8).
KeywordsProtein Carrier Iodoacetic Acid Crosslinking Reagent Conjugate Formation Contact Protein
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