The Plasma Membrane ‘Skeleton’ of Tumor and Lymphoid Cells: A Role in Cell Lysis?
A detailed understanding of the structure and dynamics of the surface membrane of cells is crucial to study of the mechanisms of cell mediated cytotoxicity. The dynamics of the membrane receptors, target cell antigens and accessory proteins almost certainly affect the efficiency of establishing and maintaining cell-cell contact and delivery of the transmembrane signal resulting in triggering of the lytic mechanisms. Furthermore, whether the primary event involved in target cell lysis is formation of membrane lesions (pore formation) or transfer of a lytic component (enzyme?) from the effector cell to the target, the molecular requirements for these events will certainly depend upon the structure and dynamics of the target cell plasma membrane.
KeywordsLymphoid Cell Insoluble Fraction Membrane Matrix Peripheral Layer Membrane Skeleton
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