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The Role of the T3 Molecular Complex on Human T Lymphocyte-Mediated Cytotoxicity

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Mechanisms of Cell-Mediated Cytotoxicity II

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 184))

Abstract

The mechanism via which cytotoxic T lymphocytes (CTL)1-lyse their target cells remains a mystery. The recent development of monoclonal antibodies that react with function-associated molecules on the surfaces of human or murine T cells has provided useful reagents for the delineation of the mechanism of CTL function. One such function-associated molecule is the T3 molecular complex present on the surfaces of all mature human T cells (1). Monoclonal antibodies to the T3 complex have diverse effects on T cell function including induction of prolIferatlon of resting T cells (2,3), inhibition of CTL generation in vitro (4), and inhibition of effector CTL function in lytic assays (3,5–7). In the present report, we will discuss these properties of the monoclonal antibodies placing emphasis on the inhibition of CTL- medfated lysis of target cells.

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Authors and Affiliations

  1. Department of Basic and Clinical Research, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, California, USA

    Constantine D. Tsoukas, Mary Valentine, Martin Lotz, John H. Vaughan & Dennis A. Carson

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  1. Constantine D. Tsoukas
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  2. Mary Valentine
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  3. Martin Lotz
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  4. John H. Vaughan
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  5. Dennis A. Carson
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Editors and Affiliations

  1. National Institutes of Health, Bethesda, Maryland, USA

    Pierre Henkart

  2. University of Massachusetts, Amherst, Massachusetts, USA

    Eric Martz

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© 1985 Plenum Press, New York

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Tsoukas, C.D., Valentine, M., Lotz, M., Vaughan, J.H., Carson, D.A. (1985). The Role of the T3 Molecular Complex on Human T Lymphocyte-Mediated Cytotoxicity. In: Henkart, P., Martz, E. (eds) Mechanisms of Cell-Mediated Cytotoxicity II. Advances in Experimental Medicine and Biology, vol 184. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-8326-0_25

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  • DOI: https://doi.org/10.1007/978-1-4684-8326-0_25

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