The Role of the T3 Molecular Complex on Human T Lymphocyte-Mediated Cytotoxicity

  • Constantine D. Tsoukas
  • Mary Valentine
  • Martin Lotz
  • John H. Vaughan
  • Dennis A. Carson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 187)


The mechanism via which cytotoxic T lymphocytes (CTL)1-lyse their target cells remains a mystery. The recent development of monoclonal antibodies that react with function-associated molecules on the surfaces of human or murine T cells has provided useful reagents for the delineation of the mechanism of CTL function. One such function-associated molecule is the T3 molecular complex present on the surfaces of all mature human T cells (1). Monoclonal antibodies to the T3 complex have diverse effects on T cell function including induction of prolIferatlon of resting T cells (2,3), inhibition of CTL generation in vitro (4), and inhibition of effector CTL function in lytic assays (3,5–7). In the present report, we will discuss these properties of the monoclonal antibodies placing emphasis on the inhibition of CTL- medfated lysis of target cells.


Antigen Receptor Conjugate Formation Antibody OKT3 Lytic Assay Preform Conjugate 


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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Constantine D. Tsoukas
    • 1
  • Mary Valentine
    • 1
  • Martin Lotz
    • 1
  • John H. Vaughan
    • 1
  • Dennis A. Carson
    • 1
  1. 1.Department of Basic and Clinical ResearchScripps Clinic and Research FoundationLa JollaUSA

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