Functional Relationships of LYT-2 and LYT-3 Expression and T-Cell Cytotoxicity: A New Model System
Three systems of surface antigens, Lyt-1, Lyt-2 and Lyt-3, characterize cells of thymic origin in the mouse.1 Lyt-1 antigens, coded by a locus with two alleles on chromosome 19, appear to be expressed on all classes of T-cells.2 Lyt-2 and Lyt-3 antigens on the other hand, clearly distinguish subclasses of T-cells.3,4 Cytotoxic and suppressor T-cells express Lyt-2 and Lyt-3, whereas helper T-cells generally lack these antigens. Lyt-2 and Lyt-3 are coded for by a single gene or closely linked genes on chromosome 6.5
KeywordsKilling Activity Mixed Lymphocyte Culture Allelic Exclusion Light Chain Variable Region Immunoglobulin Kappa Light Chain
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