Functional Relationships of LYT-2 and LYT-3 Expression and T-Cell Cytotoxicity: A New Model System

  • Michael A. PalladinoJr.
  • Gerald E. Ranges
  • Herbert F. Oettgen
  • Lloyd J. Old
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 187)


Three systems of surface antigens, Lyt-1, Lyt-2 and Lyt-3, characterize cells of thymic origin in the mouse.1 Lyt-1 antigens, coded by a locus with two alleles on chromosome 19, appear to be expressed on all classes of T-cells.2 Lyt-2 and Lyt-3 antigens on the other hand, clearly distinguish subclasses of T-cells.3,4 Cytotoxic and suppressor T-cells express Lyt-2 and Lyt-3, whereas helper T-cells generally lack these antigens. Lyt-2 and Lyt-3 are coded for by a single gene or closely linked genes on chromosome 6.5


Killing Activity Mixed Lymphocyte Culture Allelic Exclusion Light Chain Variable Region Immunoglobulin Kappa Light Chain 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Michael A. PalladinoJr.
    • 1
    • 3
  • Gerald E. Ranges
    • 2
    • 3
  • Herbert F. Oettgen
    • 3
  • Lloyd J. Old
    • 3
  1. 1.Department of Pharmacological Sciences/ImmunologyGenentech, Inc.South San FranciscoUSA
  2. 2.Department of MedicineUniversity of Vermont College of MedicineBurlingtonUSA
  3. 3.Memorial Sloan Kettering Cancer CenterNew YorkUSA

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