The Lipoxygenase Pathway in the Human NK Cell System

  • Mikael Jondal
  • Charlotte Kullman
  • Jan-Åke Lindgren
  • Paolo Rossi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 187)


Induction of cell-mediated cytotoxicity requires trans-membrane signalling as in other lymphocyte activation systems. Earlier studies have pointed to the importance of arachidonic acid (AA) metabolites in regulating different cytotxicity systems (l–4a+4b). In the human NK cell system Seaman recently showed that antagonists of lipoxygenation such as nordihydroquaiaretic acid (NDGA) and 3-amino-l-m-(trifluoromethyl)-phenyl-2-pyrazoline (BW 755C) rapidly supress killing (5) and Suthanthiran et al that other anti-oxidants which scavenge hydroxyl radicals are suppressive (6). Hattori et al have demonstrated that purified lipomodulin, which selectivly inhibit phospholipase A2 activity, also inhibit NK cell killing (7). Using virally infected adenoma cells as target cells, Rola-Pleszynski demonstrated induction of NK cell activity with leukotriene B4 (LTB4) (8).


Natural Killer Natural Killer Cell Natural Killer Cell Cytotoxicity Human Natural Killer Cell Lipoxygenase Product 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Mikael Jondal
    • 1
  • Charlotte Kullman
    • 1
  • Jan-Åke Lindgren
    • 1
    • 2
  • Paolo Rossi
    • 1
  1. 1.Department of ImmunologyKarolinska InstitutetStockholmSweden
  2. 2.Department of Physiological ChemistryKarolinska InstitutetStockholmSweden

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