Phototherapy of Hyperbilirubinemia

  • T. R. C. Sisson
  • T. P. Vogl
Part of the Photobiology book series (PB)


Jaundice occurs in about half of all newly born infants, and is the visible expression of high concentrations of bilirubin in the circulating plasma. Bilirubin, a tetrapyrrole pigment derived from the heme moiety of hemoglobin, is carried in plasma bound primarily to albumin; small amounts may also be bound to red cell membranes. If the production of bilirubin exceeds the infant’s ability to conjugate and excrete it, this pigment accumulates in the circulation, a condition called “hyperbilirubinemia,” and thence is deposited in the skin and other tissues. If the amount of bilirubin in the plasma exceeds the available binding sites, it is believed to circulate in a free (unbound or loosely bound) form that can enter and damage the neural tissue of the brain, especially the basal ganglia.


Serum Bilirubin Fluorescent Lamp Exchange Transfusion Neonatal Jaundice Neonatal Hyperbilirubinemia 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • T. R. C. Sisson
    • 1
  • T. P. Vogl
    • 2
  1. 1.Department of PediatricsRutgers University School of MedicinePerth AmboyUSA
  2. 2.Departments of Radiology and PediatricsColumbia University College of Physicians and SurgeonsNew YorkUSA

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