Skip to main content

Correlation of the Cerebral Biochemical and Functional Effects of Monoamine Oxidase Inhibitor Antidepressants

  • Chapter
Recent Advances in Biological Psychiatry

Abstract

One group of so-called antidepressants belongs to the monoamine oxidase (MAO) inhibitors. It therefore seemed instructive to examine the correlation between the chemical and functional changes induced in the brain by monoamine oxidase inhibitors and to ask how these are related to an antidepressant action.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Marrazzi, A. S., and Hart, E. R.: The relationship of hallucinogens to adrenergic cerebral neurohumors, Science 121: 365, 1955.

    Article  PubMed  CAS  Google Scholar 

  2. Gluckman, M. L, Hart, E. R., and Marrazzi, A. S.: Cerebral synaptic inhibition by serotonin and iproniazid, ibid. 126: 448, 1957.

    CAS  Google Scholar 

  3. Marrazzi, A. S.: Psychosis as a function of disturbed chemical regulation of cerebral synaptic transmission. Rinkel, M. P., and Denber, H. C. B., Eds.: in Chemical Concepts of Psychosis, Proc. Symp. Second Internat. Congr. Psychiat. McDowell-Obolensky, New York, 1958, p. 305

    Google Scholar 

  4. Marrazzi, A. S.: A theory of hallucination on a neuropharmacologic basis. in Wortis, J., Ed.: Recent Advances in Biological Psychiatry, Vol. II, Grune and Stratton, New York, 1960, p. 333.

    Google Scholar 

  5. Horovitz, Z. P.: A Biochemical and Pharmacological Correlation of the Effects of Certain Monoamine Oxidase Inhibitors, Thesis, Univ. of Pittsburgh, 1960.

    Google Scholar 

  6. Feigl, F.: Spot Tests in Organic Analysis, Elsevier Publishing Co., Amsterdam, 1956, p. 469

    Google Scholar 

  7. Cotzias, G. C., and Dole, V. P.: Microdetermination of monoamine oxidase in tissues, J. Biol. Chem. 190: 665, 1951.

    PubMed  CAS  Google Scholar 

  8. Bogdanski, D. F., Pletscher, A., Brodie, B. B. and Udenfriend, S.: Identification and assay of serotonin in the brain, J. Pharmacol. Exp. Therap. 117: 82, 1956.

    CAS  Google Scholar 

  9. Marrazzi, A. S.: Methodological problems in neuropharmacological research, in Wortis, J., Ed.: Recent Advances in Biological Psychiatry, Vol. II, Grune and Stratton, New York, 1960. p. 379.

    Google Scholar 

  10. Marrazzi, A. S.: The effects of certain drugs on cerebral synapses. in The Pharmacology of Psychotomimetic and Psychotherapeutic Drugs, Ann. N.Y. Acad. Sci. 66:496, 1957.

    Google Scholar 

  11. Marrazzi, A. S.: Synaptic and behavioral correlates of psychotherapeutic and related drug actions, in Some Biological Aspects of Schizophrenic Behavior, ibid., 96: 211, 1962.

    Google Scholar 

  12. Marrazzi, A S.: Inhibition as a determinant of synaptic and behavioral patterns. in Pavlovian Conference on Higher Nervous System Activity, ibid., 92: 990, 1961

    CAS  Google Scholar 

  13. Unpublished data from these laboratories.

    Google Scholar 

  14. Bailey, S. d’A., Bucci, L., Gosline, E., Kline, N. S., Park, I. H., Rochlin, D., Saunders, J. C., and Vaisberg, M.: Comparison of iproniazid with other amine oxidase inhibitors. in Amine Oxidase Inhibitors, ibid. 80: 643, 1959.

    Google Scholar 

  15. Goldman, D.: Clinical experience with newer antidepressant drugs and some related electroencephalographic observations, ibid. 80: 687, 1959.

    CAS  Google Scholar 

  16. Freedman, D. X. and Giarman, N. J.: Fed. Proc. 19: 266, 1960.

    Google Scholar 

  17. Bergen, J. R. and Beisaw, N. E.: Fed. Proc. 15: 15, 1956.

    Google Scholar 

  18. Hoagland, H., Rinkel, M., and Hyde, R. W.: A.M.A. Arch. Neurol. Psychiat. 73: 100, 1955.

    CAS  Google Scholar 

  19. Gertner, S. B.: Nature 183: 750, 1959.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1962 Plenum Press Inc.

About this chapter

Cite this chapter

Marrazzi, A.S., Hart, E.R., Rodriguez, J.M., Gluckman, M.I., Horovitz, Z.P., Himwich, H.E. (1962). Correlation of the Cerebral Biochemical and Functional Effects of Monoamine Oxidase Inhibitor Antidepressants. In: Wortis, J. (eds) Recent Advances in Biological Psychiatry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8306-2_25

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-8306-2_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8308-6

  • Online ISBN: 978-1-4684-8306-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics