Interaction of Monoamine Oxidase Inhibitors with Imipramine and Similar Drugs

  • Williamina A. Himwich


Over the past two years we have been studying the effects of imipramine (Tofranil) given with tranylcypromine (Parnate) in dogs in hopes of elucidating the mechanism responsible for the toxic effects of this combination and also the basic mechanism of action of imipramine. Detailed descriptions of the behavioral reaction have been published elsewhere [1, 2]. More recently, clinical reports of disastrous results of the use of imipramine with a monoamine oxidase inhibitor (MAOI) have appeared [3–6].


Monoamine Oxidase Inhibitor Anesthetize Animal Rhythmic Movement Brain Serotonin Muscle Twitching 
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    Himwich, Williamina A., Costa, E., and Himwich, H. E.: Brain serotonin in relation to imipramine interaction with a monoamine oxidase inhibitor. in Rothlin, E., Ed.: Neuropsychopharmacology, Vol. I I, Van Nostrand, New York, 1960.Google Scholar
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Copyright information

© Plenum Press Inc. 1962

Authors and Affiliations

  • Williamina A. Himwich

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