Interaction of Monoamine Oxidase Inhibitors with Imipramine and Similar Drugs
Over the past two years we have been studying the effects of imipramine (Tofranil) given with tranylcypromine (Parnate) in dogs in hopes of elucidating the mechanism responsible for the toxic effects of this combination and also the basic mechanism of action of imipramine. Detailed descriptions of the behavioral reaction have been published elsewhere [1, 2]. More recently, clinical reports of disastrous results of the use of imipramine with a monoamine oxidase inhibitor (MAOI) have appeared [3–6].
KeywordsMonoamine Oxidase Inhibitor Anesthetize Animal Rhythmic Movement Brain Serotonin Muscle Twitching
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- 1.Himwich, Williamina A., Costa, E., and Himwich, H. E.: Brain serotonin in relation to imipramine interaction with a monoamine oxidase inhibitor. in Rothlin, E., Ed.: Neuropsychopharmacology, Vol. I I, Van Nostrand, New York, 1960.Google Scholar
- 3.Singh, H.: Atropine-like poisoning due to tranquilizing agents, Am. J. Psychiat. 117: 360, 1960.Google Scholar
- 5.Luby, E.D. and Domino, E. F.: Increased drug.toxicity resulting from large doses of imipramine (Tofranil) and an MAO inhibitor in a patient with suicidal intent, in press.Google Scholar
- 6.Ayd, F. J., Jr.: Toxic somatic and psychopathologic reactions to antidepressant drugs, in press.Google Scholar
- 7.Himwich, Williamina A., and Costa, E.: Behavioral changes associated with changes in concentrations of brain serotonin, Fed. Proc. 19: 838, 1960.Google Scholar
- 8.Benedict, F. G., and Cathcart, E. P.: Muscular work. Ametabolic study, with special reference to the efficiency of the human body as a machine, Carnegie Inst. of Washington, No. 187, 1913.Google Scholar
- 9.Meter, W. G. van, Owens, H. F., and Himwich, H. E.: Effects of Tofranil, an antidepressant drug, on electrical potentials of rabbit brain, Canadian Psychiat. Assoc. J. 4: S113, 1959.Google Scholar
- 10.Morpurgo, C.: Personal communication.Google Scholar
- 11.Sulser, F., Watts, J. F., and Brodie, B. B.: Blocking of reserpine action by imipramine, a drug devoid of stimulatory effects in normal animals, Fed. Proc. 20: 321, 1961.Google Scholar