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Interaction of Monoamine Oxidase Inhibitors with Imipramine and Similar Drugs

  • Williamina A. Himwich

Abstract

Over the past two years we have been studying the effects of imipramine (Tofranil) given with tranylcypromine (Parnate) in dogs in hopes of elucidating the mechanism responsible for the toxic effects of this combination and also the basic mechanism of action of imipramine. Detailed descriptions of the behavioral reaction have been published elsewhere [1, 2]. More recently, clinical reports of disastrous results of the use of imipramine with a monoamine oxidase inhibitor (MAOI) have appeared [3–6].

Keywords

Monoamine Oxidase Inhibitor Anesthetize Animal Rhythmic Movement Brain Serotonin Muscle Twitching 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Himwich, Williamina A., Costa, E., and Himwich, H. E.: Brain serotonin in relation to imipramine interaction with a monoamine oxidase inhibitor. in Rothlin, E., Ed.: Neuropsychopharmacology, Vol. I I, Van Nostrand, New York, 1960.Google Scholar
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    Himwich, Williamina A., and Petersen, J. C.: Effect of the combined administration of imipramine and a monoamine oxidase inhibitor, Am. J. Psychiat. 117: 928, 1961.PubMedGoogle Scholar
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    Meter, W. G. van, Owens, H. F., and Himwich, H. E.: Effects of Tofranil, an antidepressant drug, on electrical potentials of rabbit brain, Canadian Psychiat. Assoc. J. 4: S113, 1959.Google Scholar
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Copyright information

© Plenum Press Inc. 1962

Authors and Affiliations

  • Williamina A. Himwich

There are no affiliations available

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