A Note on Direct Separation of Mefloquine Enantiomers by Liquid Chromatography on a Urea-Linked Chiral Stationary Phase
(2-Piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol (structure shown in Figure 1) has two asymmetric carbons. Both erythro- and threo-diastereoisomers have been synthesised and the erythro-isomer (mefloquine) is now used as an antimalarial agent. Here we report some preliminary results on the separation of the enantiomers of mefloquine by liquid chromatography.
KeywordsCarbonyl Oxygen Capacity Factor Ammonium Salt Chiral Stationary Phase Chiral Separation
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