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A Note on Direct Separation of Mefloquine Enantiomers by Liquid Chromatography on a Urea-Linked Chiral Stationary Phase

  • F. Gimenez
  • F. Bertrand
  • M. Bouley
  • A. Thuillier
  • G. Hazebroucq
  • R. Farinotti
Part of the Chromatographic Society Symposium Series book series (CSSS)

Abstract

(2-Piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol (structure shown in Figure 1) has two asymmetric carbons. Both erythro- and threo-diastereoisomers have been synthesised and the erythro-isomer (mefloquine) is now used as an antimalarial agent. Here we report some preliminary results on the separation of the enantiomers of mefloquine by liquid chromatography.

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Reference

  1. 1.
    F. I. Carroll and J. T. Blackwell, J. Med. Chem., 17: 210–219 (1974).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • F. Gimenez
    • 1
    • 2
  • F. Bertrand
    • 3
  • M. Bouley
    • 2
  • A. Thuillier
    • 2
  • G. Hazebroucq
    • 1
  • R. Farinotti
    • 1
    • 3
  1. 1.Laboratoire de Pharmacie CliniqueUniversité Paris XI Chatenay-MalabryFrance
  2. 2.Service de Pharmacie-PharmacocinétiqueHôpital Pitié-SalpétrièreParisFrance
  3. 3.Service de Pharmacie Clinique et des BiomatériauxHôpital BichatParisFrance

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