A Note on Direct Separation of Mefloquine Enantiomers by Liquid Chromatography on a Urea-Linked Chiral Stationary Phase
(2-Piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol (structure shown in Figure 1) has two asymmetric carbons. Both erythro- and threo-diastereoisomers have been synthesised and the erythro-isomer (mefloquine) is now used as an antimalarial agent. Here we report some preliminary results on the separation of the enantiomers of mefloquine by liquid chromatography.
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