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Separation and Assignment of the Stereoisomers of β-(p-Chlorophenyl) Glutamic Acid by Ligand Exchange Chromatography

  • P. M. Udvarhelyi
  • D. C. Sunter
  • J. C. Watkins
Part of the Chromatographic Society Symposium Series book series (CSSS)

Summary

The resolution of β-(p-chlorophenyl) glutamic acid and β-phenylglutamic acid into two pairs of enantiomers was accomplished by chiral ligand exchange chromatography (LEC). The configurations of the four separated stereoisomers of β-(p-chlorophenyl) glutamic acid at the α-centre were determined by chiroptical spectroscopy. From these measurements it was also possible to establish which of the stereoisomers were enantiomers.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • P. M. Udvarhelyi
    • 1
  • D. C. Sunter
    • 1
  • J. C. Watkins
    • 1
  1. 1.Department of PharmacologyMedical School, University of BristolBristolUK

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