Separation and Assignment of the Stereoisomers of β-(p-Chlorophenyl) Glutamic Acid by Ligand Exchange Chromatography
The resolution of β-(p-chlorophenyl) glutamic acid and β-phenylglutamic acid into two pairs of enantiomers was accomplished by chiral ligand exchange chromatography (LEC). The configurations of the four separated stereoisomers of β-(p-chlorophenyl) glutamic acid at the α-centre were determined by chiroptical spectroscopy. From these measurements it was also possible to establish which of the stereoisomers were enantiomers.
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