Separation and Assignment of the Stereoisomers of β-(p-Chlorophenyl) Glutamic Acid by Ligand Exchange Chromatography

  • P. M. Udvarhelyi
  • D. C. Sunter
  • J. C. Watkins
Part of the Chromatographic Society Symposium Series book series (CSSS)


The resolution of β-(p-chlorophenyl) glutamic acid and β-phenylglutamic acid into two pairs of enantiomers was accomplished by chiral ligand exchange chromatography (LEC). The configurations of the four separated stereoisomers of β-(p-chlorophenyl) glutamic acid at the α-centre were determined by chiroptical spectroscopy. From these measurements it was also possible to establish which of the stereoisomers were enantiomers.


Circular dichrOism Spectrum Chiral Selector Chiral Separation Circular dichrOism Band Configurational Isomer 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • P. M. Udvarhelyi
    • 1
  • D. C. Sunter
    • 1
  • J. C. Watkins
    • 1
  1. 1.Department of PharmacologyMedical School, University of BristolBristolUK

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