Separation and Assignment of the Stereoisomers of β-(p-Chlorophenyl) Glutamic Acid by Ligand Exchange Chromatography
The resolution of β-(p-chlorophenyl) glutamic acid and β-phenylglutamic acid into two pairs of enantiomers was accomplished by chiral ligand exchange chromatography (LEC). The configurations of the four separated stereoisomers of β-(p-chlorophenyl) glutamic acid at the α-centre were determined by chiroptical spectroscopy. From these measurements it was also possible to establish which of the stereoisomers were enantiomers.
KeywordsCircular dichrOism Spectrum Chiral Selector Chiral Separation Circular dichrOism Band Configurational Isomer
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