A Note on the Use of Reciprocal Interaction in the Design of Pyrethroid Specific Chiral Stationary Phases
We have attempted to design chiral stationary phases (CSPs) to resolve all the stereoisomers of the insecticide Cypermethrin (Structure 1) using the principle of reciprocal interaction. In order to do this Cypermethrin has been structurally modified to enable it to be bonded to silica, and the resulting CSP will be used to identify and optimise the interactions of racemic structures from which a single enantiomer will be bound to silica to afford a Cypermethrin-specific CSP.
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