The Design of Chiral Separations for β-Blocker Drugs on Pirkle High-Performance Liquid Chromatography Phases Using Achiral Derivatisation

  • A. M. Dyas
  • M. L. Robinson
  • A. F. Fell
Part of the Chromatographic Society Symposium Series book series (CSSS)


The chromatographic performance of a series of isocyanate and isothiocyanate derivatives of (+/−)-propranolol on three Pirkle phases was investigated. For each phase the choice of urea or thiourea derivative had a consistent effect on retention although not on resolution. The relationship between structure and retention on π-acidic amino acid phases is explicable although this cannot be extended to separations observed. Inversion of elution order of the (+)- and (−)-enantiomers was observed for some derivatives on the covalent 1-leucine phase which further hinders the attempt to link structure to resolution for predictive method development purposes. The α-naphthyl and phenyl derivatives generally gave good resolution of enantiomers.


Elution Order Chiral Separation Urea Derivative Chromatographic Performance Thiourea Derivative 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • A. M. Dyas
    • 1
  • M. L. Robinson
    • 1
  • A. F. Fell
    • 2
  1. 1.International Development LaboratoryBristol-Myers SquibbMoreton MerseysideUK
  2. 2.Department of Pharmaceutical Chemistry School of PharmacyUniversity of BradfordBradfordUK

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