A Note on Some Examples of Chiral High-Performance Liquid Chromatographic Resolution in the Pharmaceutical Industry
Examples of the methods by which enantiomers may be resolved chromatographically using either preliminary derivatisation with a chiral reagent, direct separation using a chiral mobile phase, or by direct separation using a chiral stationary phase (CSP) are outlined. These methods are illustrated by reference to chiral resolutions of compounds of interest to Glaxo Group Research Limited.
KeywordsChiral Stationary Phase Chromatographic Resolution Ammonium Dihydrogen Ammonium Dihydrogen Phosphate Chiral Resolution
Unable to display preview. Download preview PDF.