A Note on Some Examples of Chiral High-Performance Liquid Chromatographic Resolution in the Pharmaceutical Industry
Examples of the methods by which enantiomers may be resolved chromatographically using either preliminary derivatisation with a chiral reagent, direct separation using a chiral mobile phase, or by direct separation using a chiral stationary phase (CSP) are outlined. These methods are illustrated by reference to chiral resolutions of compounds of interest to Glaxo Group Research Limited.
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