Is There a Rational Basis for the Selection and/or Design of Chiral Stationary Phases for High-Performance Liquid Chromatography?

  • David R. Taylor
Part of the Chromatographic Society Symposium Series book series (CSSS)


One of the major problems facing the analyst in chiral high-performance liquid chromatography (HPLC) is that of selecting an appropriate chiral stationary phase (CSP) for a given analysis. Here an attempt is made to address the problem by proposing a simple algorithm for use in CSP selection, based upon Wainer’s classification of the five main types of CSP.

The prospect of using computer-assisted molecular modelling (CAMM) to assist in this area has aroused much interest, and several case histories of such investigations are described. These case histories highlight not only the power of CAMM in modelling diastereoisomeric interaction complexes, but also the associated problems which can arise.

In addition, suggestions for other approaches to the design of new CSPs are made, including work based upon both reciprocity of interaction and the development of new families of CSPs.


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • David R. Taylor
    • 1
  1. 1.Chemistry DepartmentUMISTManchesterUK

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