An Evaluation of Some Chiral Stationary Phases for the Separation of β-Blocker Drugs

  • G. A. Kingston
  • D. Stevenson
Part of the Chromatographic Society Symposium Series book series (CSSS)


Three different chiral stationary phases have been evaluated for their ability to resolve racemic propranolol and other β-blocker drugs. Cyclobond 1 was not successful in separating underivatised propranolol. αl-Acid glycoprotein successfully separated the drugs atenolol, alprenolol, metoprolol, oxprenolol, practolol, pronethalol and propranolol into their enantiomers. Separations for propranolol, pronethalol, oxprenolol, metoprolol and alprenolol as their 1- or 2-naphthamide derivatives were achieved on a covalent 3,5-dinitrobenzoyl phenylglycine phase. The derivatisation reaction was rapid and quantitive.


Mobile Phase Composition Chiral Stationary Phasis Amino Alcohol Derivatisation Reaction Metoprolol Tartrate 


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • G. A. Kingston
    • 1
  • D. Stevenson
    • 1
  1. 1.Robens Institute of Health and SafetyUniversity of SurreyGuildford, SurreyUK

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