Serine and Metallo Proteinases in Acute Renal Failure

  • Roland M. Schaefer
  • Christopher Wanner
  • Walter H. Hörl
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 212)


Recent studies have demonstrated frank proteolytic activity in plasma fractions of patients with acute renal failure (ARF) following traumatic injuries and/or septicemia 1–3. Therefore, it was assumed that proteases play a key role in the catabolic state of ARF 4. Since hemodialysis may even cause a further release of leukocyte proteinases, which has been widely documented for elastase 5–7, one was frightened that the very measure to relieve the burden of ARF might contribute to the catabolism of this state. Therefore, the present study was performed to further characterize this proteolytic activity in the plasma of such patients.


Acute Renal Failure Proteolytic Activity Plasma Fraction Gamma Subunit Phosphorylase Kinase 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Roland M. Schaefer
    • 1
  • Christopher Wanner
    • 2
  • Walter H. Hörl
    • 2
  1. 1.Department of Medicine, Division of NephrologyUniversities of WuerzburgGermany
  2. 2.Department of Medicine, Division of NephrologyUniversities of FreiburgGermany

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