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Filtration Pressure and Glomerular Permeability in HgCl2-Acute Renal Failure in the Dog

  • Raymond Vanholder
  • Pierre Paul Lambert
  • Norbert Lameire
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 212)

Abstract

There are essentially four mechanisms that can explain the filtration fall that is observed during experimental acute renal failure: tubular back-leakage, tubular obstruction, a decrease of glomerular permeability and a fall in effective filtration pressure due to hemodynamic changes. The studies that make an attempt to characterize these different mechanisms are rare and focus in most of the cases on the maintenance phase but not on the initiation phase of acute renal failure.

Keywords

Acute Renal Failure Renal Blood Flow Filtration Pressure Colloid Osmotic Pressure Glomerular Permeability 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    VANRENTERGHEM Y., VANHOLDER R., LAMMENS-VERSLYPE M. and LAMBERT P.P.: Sieving studies in “urea-induced nephropathy” in the dog. Clin. Science, 58, 65–75, 1980.Google Scholar
  2. 2.
    MYERS B.D., CHUI F., HILBERMAN M. and MICHAELS A.S.: Transtubular leakage of glomerular filtrate in human acute renal failure. Am. J. Physiol., 237, F319 - F325, 1979.PubMedGoogle Scholar
  3. 3.
    MYERS B.D., HILBERMAN M., SPENCER R.J. and JAMISON R.L.: Glomerular and tubular function in non-oliguric acute renal failure. Am. J. Med., 72, 642–649, 1982.PubMedCrossRefGoogle Scholar
  4. 4.
    DI BONA G.F., MAC DONALD F.D., FLAMENBAUM W.,DAMMIN G. J. and OKEN D.E.: Maintenance of renal function in salt loaded rats despite severe tubular necrosis induced by HgC12. Nephron, 8, 205–220, 1971.Google Scholar
  5. 5.
    FLAMENBAUM W., MAC DONALD F.D., DI BONA G.F. and OKEN D.E.: Micropuncture study of renal tubular factors in low dose mercury poisoning. Nephron, 8, 221–234, 1971.PubMedCrossRefGoogle Scholar
  6. 6.
    OLBRICHT C., MASON J., TAKABATAKE T., HOHLBRUGGER G. and THURAU K.: The early phase of experimental acute renal failure. II. Tubular leakage and the reliability of glomerular markers. Pflügers Arch., 372, 251–258, 1977.PubMedCrossRefGoogle Scholar
  7. 7.
    BRENNER B.M., BOHRER M.P., BAYLIS C. and DEEN W.M.: Determinants of glomerular permselectivity: insights derived from observations in vivo. Kidney Int., 12, 229–237, 1977.PubMedCrossRefGoogle Scholar
  8. 8.
    DU BOIS R., DECOODT P., GASSEE J.P., VERNIORY A. and LAMBERT P.P.: Determination of glomerular intracapillary and transcapillary pressure gradients from sieving data.I. Mathematical model. Pflügers Arch., 356, 299–316, 1975.PubMedCrossRefGoogle Scholar
  9. 9.
    NAVAR L.G., BELL P.D., WHITE R.W., WATTS R.L. and WILLIAMS R.H.: Evaluation of the single nephron glomerular filtration coefficient in the dog. Kidney Int., 12, 137–149, 1977.PubMedCrossRefGoogle Scholar
  10. 10.
    SAVIN V.J., PATAK R.V., MARR G., HERMRECK A.S., RIDGE VENKATACHALAM M., REINECK J. and STEIN J.: In vitro perfusion of the iso-lated dog glomerulus. Am. J. Physiol., 244, F349 - F354, 1983.Google Scholar
  11. 12.
    LAMBERT P.P., AEIKENS G. and BERGMANN P.: Microrheology, water permeability and permselectivity for macromolecules in the renal glomerulus. In: The paracellular pathway. Ed. S.E. Bradley and E.F. Purcell, Josiah Macy Jr. Foundation, 1982, pp. 97–117.Google Scholar
  12. 13.
    VANHOLDER R., LEUSEN I. and LAMEIRE N.: Influence of isotonic mannitol and saline in HgC12-induced acute renal failure. Nephron, 23, 744–748, 1983.Google Scholar
  13. 14.
    VANHOLDER R., MATTHYS E., LEUSEN I. and LAMEIRE N.: Effect of premercurial resetting of intrarenal vascular resistance on HgC12-induced acute renal failure.J. Clin. Lab. Med., in press.Google Scholar
  14. 15.
    VANHOLDER R. and LAMEIRE N.: Effect of captopril on HgC12-induced acute renal failure (ARF-). Abstracts of the IXth international congress of nephrology, Los Angeles, 1984, p. 338A.Google Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Raymond Vanholder
    • 1
    • 2
  • Pierre Paul Lambert
    • 1
    • 2
  • Norbert Lameire
    • 1
    • 2
  1. 1.Renal DivisionUniversity HospitalGentBelgium
  2. 2.Queen Elisabeth FoundationBrusselsBelgium

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