Protection from Acute Renal Failure

  • Michel Burnier
  • Robert W. Schrier
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 212)


The occurrence of acute renal failure (ARF), defined as an acute impairment of renal function resulting in the accumulation of nitrogenous waste which cannot be reversed by altering extrarenal factors, is frequent in contemporary medicine. In a recent prospective study, 4.9% of 2216 in-hospital patients developed some degree of ARF, and in some particular clinical situations, such as intensive care medicine or following cardiovascular surgery, the percentage of patients presenting with ARF may be as high as 50% (1,2). ARF is a major problem in clinical medicine not only because of its frequency but also because it represents a major cause of morbidity and mortality (1). Thus, the development of effective means to protect the kidneys against ischemic or nephrotoxic insults is very important in order to decrease the incidence of ARF and its related complications.


Glomerular Filtration Rate Acute Renal Failure Calcium Channel Blocker Renal Blood Flow Vasoactive Agent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Michel Burnier
    • 1
  • Robert W. Schrier
    • 1
  1. 1.Department of MedicineUniversity of Colorado School of MedicineDenverUSA

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