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Influence of Some Uremic Toxins on Oxygen Consumption of Rats in Vivo and in Vitro

  • M. Hohenegger
  • H. Echsel
  • M. Vermes
  • H. Raneburger
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 212)

Abstract

Hypothermia has been reported as a symptom of uremic patients.1,9,11 Body temperatures between 33 and 34 °C are regularly observed in rats, 24 hours after bilateral nephrectomy.10 This phenomenon was studied by our group during the last years and the following results were obtained:
  1. 1.

    Hypothermia is secondary to a severe reduction of the metabolic rate because nephrectomized rats, maintained at a normal body temperature by housing them in a thermostat, did not improve oxygen consumption.l0

     
  2. 2.

    Hypothermia and hypometabolism occur at a normal pO2 of arterial blood, a rather elevated blood pressure10 and a normal cardiac output (unpublished results).

     
  3. 3.

    Correction of extracellular pH in uremia by bicarbonate treatment does not ameliorate the metabolic situation.10

     
  4. 4.

    Pretreatment with triiodothyronine (T3) over a period of 3 days does not prevent the reduction of oxygen consumption following nephrectomy.6 As such a pretreatment prevents the reduction of the metabolic rate in cyanide, fluoride and digitoxin intoxication, the lacking effect of T3 in uremia may be considered to some degree as a specific phenomenon.4

     
In a further series of experiments we investigated whether some of the so-called uremic toxins were able to induce a similar reduction of oxygen consumption in normal rats.

Keywords

Oxygen Consumption Liver Slice Uremic Patient Uremic Toxin Oxygen Saturation Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • M. Hohenegger
    • 1
  • H. Echsel
    • 1
  • M. Vermes
    • 1
  • H. Raneburger
    • 1
  1. 1.Institute of General and Experimental PathologyUniversity of ViennaAustria

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