Advertisement

Intracellular Acid-Base and Energy Metabolism in Oliguric Acute Renal Failure (OARF)

  • A. Guariglia
  • C. Antonucci
  • U. Arduini
  • S. Del Canale
  • E. Coffrini
  • P. Vitali
  • E. Fiaccadori
  • Alberico Borghetti
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 212)

Abstract

Acute renal failure is often associated with a condition of metabolic acidosis. However, extracellular acid-base parameters do not seem to be fully representative of the entity of retained acids, since it is the intracellular compartment which is mainly involved in buffering of the acid load (1–2).

Keywords

Acid Load High Energy Phosphate Alkali Therapy Oliguric Acute Renal Failure Muscle Needle Biopsy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Schwartz W.B.,Orning K.J., Porter R.: The internal distribution of hydrogen ions with varying degrees of metabolic acidosis. J. Clin. Invest. 36: 373 (1957).PubMedCrossRefGoogle Scholar
  2. 2.
    Swan R.C., Pitts R.F.: Neutralization of infused acid by nephrectomized dogs. J. Clin. Invest. 34: 205 (1955).PubMedCrossRefGoogle Scholar
  3. 3.
    Cohen R.D., Iles R.A.: Intracellular pH. CRC Crit. Rev. Clin. Lab. Sci. 101 (1975).Google Scholar
  4. 4.
    Relman A.S.: Metabolic consequences of acid-base disorders. Kidney Int. 1: 347 (1972).PubMedCrossRefGoogle Scholar
  5. 5.
    Hultman E., Sahlin K.: Acid-base balance during exercise. In “Exercise and sport sciences reviews”. Hutton R.S.–Miller D.I. eds. Franklin Institute Press. Phiadelphia pg. 41–128 (1980).Google Scholar
  6. 6.
    Bergström J.: Muscle electrolytes in man. Scand J. Clin. Lab. Invest. 14: (suppl. 68) 1 (1962).Google Scholar
  7. 7.
    Fiaccadori E., Guariglia A., Arduini U., Del Canale S., Mori G., Reni F., Vitali P., Borghetti A.: Intracellular bicarbonate and pH determination in rat skeletal muscle from acid-labile CO2 measurement by dead-stop end-point potentiometric titrations. Eur. Rev. Med. Pharm. Sci. 1: 1 (1986).Google Scholar
  8. 8.
    Harris R.C., Hultman E., Nordesjo L.O.: Glycogen,glycolytic intermediates and high energy phosphates determined in biopsy samples of musculus femoris of man at rest. Scand J. Clin. L.b. Invest. 33: 109 (1974).CrossRefGoogle Scholar
  9. 9.
    Atkinson D.E.: The energy charge of the adenylate pool as a regulatory parameter. Interaction with feed-back modifiers. Biochemistry 7: 4030 (1968).PubMedCrossRefGoogle Scholar
  10. 10.
    Kopple J.D., Cianciaruso B.: The role of nutrition in acute renal failure. In: “Acute renal failure: pathophysiology, prevention and treatment”. Andreucci V. ed.,Martinus Nijhoff Publishing, Boston. p. 423–446 (1984).Google Scholar
  11. 11.
    Bergström J., Boström H., Fürst P., Hultman E., Vinnars E. Preliminary studies of energy-rich phosphagens in muscle from severely ill patients. Crit. Care Med. 4 (4): 197, (1976).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • A. Guariglia
    • 1
  • C. Antonucci
    • 1
  • U. Arduini
    • 1
  • S. Del Canale
    • 1
  • E. Coffrini
    • 1
  • P. Vitali
    • 1
  • E. Fiaccadori
    • 1
  • Alberico Borghetti
  1. 1.Istituto di Clinica Medica e NefrologiaParmaItaly

Personalised recommendations