Effects of Endotoxin on Hemodynamics of Isolated Dog Kidney

  • Nadine Bourgeois
  • Charles Reuse
  • Jean-Marie Boeynaems
  • Michel Staroukine
  • Jean-Louis Vanherweghem
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 212)


Endotoxin have been incriminated in the pathogenesis of acute renal failure in liver disease1,2. The altered renal function has been attributed to intense renal vasoconstriction and to a fall in renal perfusion pressure. Many authors3,4,5,6,7,8,9 postulated that the vasoconstriction was due to both a direct local action of endotoxin on the renal vascular bed and to secondary systemic release of vasocontrictor agents during the systemic hypotension. In an attempt to separate the systemic hemodynamic effects of endotoxin from a direct action of these substances on the kidney, we studied the influence of exogenous endotoxin on isolated dog kidney perfusions.


Renal Blood Flow Fulminant Hepatic Failure Renin Angiotensin System Renal Perfusion Pressure Control Kidney 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Nadine Bourgeois
    • 1
  • Charles Reuse
    • 1
  • Jean-Marie Boeynaems
    • 1
  • Michel Staroukine
    • 1
  • Jean-Louis Vanherweghem
    • 1
  1. 1.Université Libre de Bruxelles (Hôpital Erasme and Hôpital Brugmann)BrusselsBelgium

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