Ion Gradients and Metabolic Activity in the Generation of Cone and Rod Responses

  • G. B. Arden
  • W. Ernst
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 24)


Several recent reports have suggested that the photoresponses of vertebrate receptors are explicable as a change in membrane permeability to sodium. In rods, evidence has been presented that the outer limb is depolarised in darkness (Toyoda et al, 1969) owing to a high sodium permeability. When this is reduced by illumination, the membrane hyperpolarises towards the potassium equilibrium potential (Sillman et al, 1969). By contrast we have concluded (Arden and Ernst, 1970) that in cones illumination produces a reduction in membrane permeability to both sodium and potassium which causes the membrane to hyperpolarise towards the chloride equilibrium potential.


Response Amplitude Sodium Glutamate Slow Peak Calcium Free Medium Tris Chloride 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. ARDEN, G.B. and W. ERNST. 1969. Nature, 223, 528.PubMedCrossRefGoogle Scholar
  2. ARDEN, G.B. and W. ERNST, 1970b. J Physiol., 211, 311.PubMedGoogle Scholar
  3. ARDEN, G.B. and W. ERNST, 1971. J. Physiol., 220, 479.Google Scholar
  4. FABER, D. 1969. Ph.D. Thesis, State Univ. of Buffalo, N.Y.Google Scholar
  5. HAGINS, W.A., R D PENN and S. YOSHIKAMI. 1970. Biophys. J., 10 380.PubMedCrossRefGoogle Scholar
  6. SILLMAN, A.L., M. ITO and T. TOMITA. 1969. Vision Res., 9, 1443.PubMedCrossRefGoogle Scholar
  7. WEINSTEIN, G.W., R.R. HOBSON and J.E. DOWLING. 1967. Nature, 215, 134.PubMedCrossRefGoogle Scholar
  8. TOYODA, J., H. NOSAKI and T. TOMITA. 1969. Vision Res., 9, 453.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • G. B. Arden
    • 1
  • W. Ernst
    • 1
  1. 1.Institute of OphthalmologyLondonEngland

Personalised recommendations